Variability in the Vestibulo-Ocular Reflex and Vestibular Perception.
Variability in the Vestibulo-Ocular Reflex and Vestibular Perception.
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DOI：
10.1016/j.neuroscience.2018.08.025
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发表时间：
2018-11-21
期刊：
影响因子：
3.3
通讯作者：
Karmali F
中科院分区：
文献类型：
--
作者：
Nouri S;Karmali F
前庭系统使人类能够估计自我运动、稳定凝视和保持姿势，但这些行为在所有处理水平上都受到神经噪声的影响（例如，感觉的、中枢的、运动的）。尽管其至关重要，噪声对人类前庭通路的行为影响尚未完全了解。在这里，我们的特点是前庭不精确，结果从神经噪声通过测量试验到试验前庭眼反射（VOR）的变化和感知的刚可察觉的差异（JND）在同一人类受试者作为刺激强度的函数。我们使用以头部为中心的偏航旋转绕地球垂直轴在一个广泛的运动速度范围内（0°/s至65°/s的VOR变化和3°/s至90°/s的JND峰值速度）。我们发现VOR变异性从1°/s的椅子速度下的约0.6°/s增加到65°/s下的约3°/s;它表现出低于约1°/s的刺激无关范围。感知不精确度（“sigma”）从3°/s时的0.76°/s增加到90°/s时的4.7°/s。使用操纵速度，位移和加速度之间的关系的刺激，我们发现，速度是我们的运动刺激VOR变异性的显着线索。VOR和知觉不精确性都随着刺激强度的增加而增加，并且在刺激速度的范围内大致相似，这与影响运动和知觉通路的常见噪声源一致。这与视觉研究中不同的知觉和运动刺激依赖的不精确性形成对比。无论是刺激依赖的噪声或非线性信号处理可以解释我们的结果，但我们认为，传入的非线性本身是不太可能的来源所观察到的行为刺激依赖的不精确性。
The vestibular system enables humans to estimate self-motion, stabilize gaze and maintain posture, but these behaviors are impacted by neural noise at all levels of processing (e.g., sensory, central, motor). Despite its essential importance, the behavioral impact of noise in human vestibular pathways is not completely understood. Here, we characterize the vestibular imprecision that results from neural noise by measuring trial-to-trial vestibulo-ocular reflex (VOR) variability and perceptual just-noticeable differences (JNDs) in the same human subjects as a function of stimulus intensity. We used head-centered yaw rotations about an Earth-vertical axis over a broad range of motion velocities (0°/s to 65°/s for VOR variability and 3°/s to 90°/s peak velocity for JNDs). We found that VOR variability increased from approximately 0.6°/s at a chair velocity of 1°/s to approximately 3°/s at 65°/s; it exhibited a stimulus-independent range below roughly 1°/s. Perceptual imprecision (“sigma”) increased from 0.76°/s at 3°/s to 4.7°/s at 90°/s. Using stimuli that manipulated the relationship between velocity, displacement and acceleration, we found that velocity was the salient cue for VOR variability for our motion stimuli. VOR and perceptual imprecision both increased with stimulus intensity and were broadly similar over a range of stimulus velocities, consistent with a common noise source that affects motor and perceptual pathways. This contrasts with differing perceptual and motor stimulus-dependent imprecision in visual studies. Either stimulus-dependent noise or non-linear signal processing could explain our results, but we argue that afferent non-linearities alone are unlikely to be the source of the observed behavioral stimulus-dependent imprecision.
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影响因子：
5.3
作者：
Clemens, Ivar A. H.;De Vrijer, Maaike;Medendorp, W. Pieter
通讯作者：
Medendorp, W. Pieter
DOI：
10.1093/gerona/56.7.m438
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