Dental amalgam restorations and children's neuropsychological function: the New England Children's Amalgam Trial.
Dental amalgam restorations and children's neuropsychological function: the New England Children's Amalgam Trial.
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DOI：
10.1289/ehp.9497
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发表时间：
2007-03
影响因子：
10.4
通讯作者：
McKinlay S
中科院分区：
文献类型：
--
作者：
Bellinger DC;Daniel D;Trachtenberg F;Tavares M;McKinlay S
人们一直担心，儿童接触牙科汞合金产生的汞蒸气会产生神经毒性。我们的目的是比较在没有接触过牙汞合金的情况下，使用牙汞合金或无汞复合材料修复龋齿的儿童的神经心理功能。我们进行了一项随机对照试验，涉及534名6至10岁的城市和农村儿童，他们每年接受5年的智力、成就、语言、记忆、学习、视觉空间技能、语言流畅性、精细运动功能、解决问题能力、注意力和执行功能等一系列测试。虽然汞合金组儿童尿汞平均浓度高于复合组（0.9 vs. 0.6 μg/g肌酐），但两组儿童的测试成绩没有显著差异。发现的差异在方向上是不一致的。使用两种累积暴露指数——汞合金表面年数和尿汞浓度——进行分析得出了类似的结果。在5年的随访期内，参与试验的儿童接触到汞合金中的单质汞，并没有对神经心理功能产生显著影响。
A concern persists that children’s exposure to mercury vapor from dental amalgams produces neurotoxicity. Our goal was to compare the neuropsychological function of children, without prior exposure to dental amalgam, whose caries were repaired using either dental amalgam or mercury-free composite materials. We conducted a randomized controlled trial involving 534 6- to 10-year-old urban and rural children who were assessed yearly for 5 years using a battery of tests of intelligence, achievement, language, memory, learning, visual–spatial skills, verbal fluency, fine motor function, problem solving, attention, and executive function. Although the mean urinary mercury concentration was greater among children in the amalgam group than the composite group (0.9 vs. 0.6 μg/g creatinine), few significant differences were found between the test scores of children in the two groups. The differences found were inconsistent in direction. Analyses using two cumulative exposure indices—surface years of amalgam and urinary mercury concentration—produced similar results. Exposure to elemental mercury in amalgam at the levels experienced by the children who participated in the trial did not result in significant effects on neuropsychological function within the 5-year follow-up period.
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影响因子：
2.6
作者：
Luglie, Pier Franca;Campus, Guglielmo;Dessole, Salvatore
通讯作者：
Dessole, Salvatore
DOI：
10.1016/s0197-2456(03)00105-3
发表时间：
2003-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
McKinlay, SM
通讯作者：
McKinlay, SM
影响因子：
6.3
作者：
Dahl, JE;Sundby, J;Jacobsen, N
通讯作者：
Jacobsen, N
影响因子：
2.9
作者：
Echeverria, D;Woods, JS;Garabedian, CE
通讯作者：
Garabedian, CE
影响因子：
2.9
作者：
Echeverria, D;Woods, JS;Garabedian, C
通讯作者：
Garabedian, C