Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease.
Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease.
复制标题
DOI：
10.1186/1475-2840-13-1
复制
发表时间：
2014-01-03
影响因子：
9.3
通讯作者：
Aravindhan V
中科院分区：
文献类型：
--
作者：
Madhumitha H;Mohan V;Deepa M;Babu S;Aravindhan V
辅助T细胞因子在2型糖尿病（T2DM）和冠状动脉疾病（CAD）共发病的慢性、低度炎症中所起的作用研究较少。在本研究中，我们测量了血清中Th1和Th2细胞因子的水平，并将其与伴有/不伴有CAD的T2DM患者的临床危险因素（胰岛素抵抗（IR）、糖化血红蛋白（HbA1c））和CAD （c -反应蛋白（CRP）、内膜中膜厚度（IMT）和增强指数（AGI））联系起来。研究对象从金奈城乡流行病学研究（CURES）中招募。采用多重细胞因子法测定对照组（n = 61）、T2DM （n = 60）、CAD （n = 23）和T2DM-CAD （n = 21）受试者的血清细胞因子谱。T2DM受试者表现为Th1-Th2混合分布。冠心病患者表现为Th1谱，Th2轻度抑制，而T2DM-CAD患者表现为Th1谱增强，Th2细胞因子强烈抑制。Th1和Th2细胞因子与FPG、HbA1c、hsCRP、IMT、AGI均呈正相关。Logistic回归分析显示il - 12的重要协会(OR = 9.3; 95%可信区间-70.7 = 3.2;p = 0.016),干扰素-γ(OR = 2.8; 95%可信区间-2.9 = 2.7,p = 0.010), il - 4 (OR = 2.7; 95%可信区间2.7 - -2.7,p = 0.010), IL-5 (OR = 1.1; 95%可信区间1.0 = -1.4;p = 0.003)和IL-13(或= 2;95% CI = 1.7 - -2.6; p = 0.017)和T2DM-CAD。总之，从目前的研究来看，从T2DM或CAD到T2DM-CAD合并症的转变似乎与Th2细胞因子的强烈下调和Th1反应的增强有关。
The role played by T helper cytokines under chronic, low grade inflammation as seen in type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) co-morbidity is less well studied. In the present study, we measured the serum levels of both Th1 and Th2 cytokines and correlated it with clinical risk factors for T2DM (Insulin Resistance (IR), Glycated haemoglobin (HbA1c)) and CAD (C-Reactive Protein (CRP), Intima Media Thickness (IMT) and Augmentation index (AGI)) in T2DM subjects with/without CAD. The study subjects were recruited from Chennai Urban Rural Epidemiology Study (CURES). Serum cytokine profile was determined by multiplex cytokine assay in Control (n = 61), T2DM (n = 60), CAD (n = 23) and T2DM-CAD (n = 21) subjects. T2DM subjects showed a mixed Th1-Th2 profile. CAD subjects presented a Th1 profile with modest Th2 suppression while T2DM-CAD subjects showed enhanced Th1 profile with strong suppression of Th2 cytokines. Both Th1 and Th2 cytokines showed a positive correlation with FPG, HbA1c, hsCRP, IMT and AGI. Logistic regression analysis revealed a significant association of IL-12 (OR = 9.3; 95% CI = 3.2-70.7; p = 0.016), IFN-γ (OR = 2.8; 95% CI = 2.7-2.9, p = 0.010), IL-4 (OR = 2.7; 95% CI 2.7-2.7, p = 0.010), IL-5 (OR = 1.1; 95% CI = 1.0-1.4; p = 0.003) and IL-13 (OR = 2; 95% CI = 1.7-2.6; p = 0.017) with T2DM-CAD. In conclusion, from the present study it appears that transition from T2DM or CAD to T2DM-CAD co-morbidity is associated with strong down regulation of Th2 cytokines and enhancement of Th1 responses.
登录
查看更多内容
影响因子：
5.2
作者：
Frostegård J
通讯作者：
Frostegård J
影响因子：
6.5
作者：
Mallat, Ziad;Taleb, Soraya;Tedgui, Alain
通讯作者：
Tedgui, Alain
影响因子：
8.2
作者：
Mohan, V;Ravikumar, R;Deepa, R
通讯作者：
Deepa, R
影响因子：
3.7
作者：
Szodoray, P.;Timar, O.;Soltesz, P.
通讯作者：
Soltesz, P.
影响因子：
9.3
作者：
LaFramboise WA;Dhir R;Kelly LA;Petrosko P;Krill-Burger JM;Sciulli CM;Lyons-Weiler MA;Chandran UR;Lomakin A;Masterson RV;Marroquin OC;Mulukutla SR;McNamara DM
通讯作者：
McNamara DM