Biomarkers Assessing Endothelial Dysfunction in Alzheimer's Disease.
Biomarkers Assessing Endothelial Dysfunction in Alzheimer's Disease.
复制标题
作者：
阿尔茨海默病（Alzheimer's disease，AD）是发达国家老年人最常见的退行性疾病。目前，越来越多的证据表明内皮功能障碍是AD认知衰退过程中的关键因素。作为血脑屏障（BBB）的主要组成部分，由与AD相关的血管风险因素驱动的内皮细胞功能障碍允许有毒物质通过脑实质，产生慢性灌注不足，最终导致炎症和神经毒性反应。在这个过程中，几种生物标志物的水平被破坏，例如粘附分子的增加，允许白细胞通过脑实质，增加BBB的渗透性;此外，其他血管参与者，包括内皮素-1，也介导动脉炎症。作为BBB破坏的结果，产生进行性神经炎症反应，其添加到星形胶质细胞增生中，最终触发神经元变性（可能导致认知退化）。最近，新的分子已被提出作为内皮功能障碍的早期生物标志物，可以构成新的治疗靶点以及AD的早期诊断和预后标志物。
Alzheimer’s disease (AD) is the most common degenerative disorder in the elderly in developed countries. Currently, growing evidence is pointing at endothelial dysfunction as a key player in the cognitive decline course of AD. As a main component of the blood–brain barrier (BBB), the dysfunction of endothelial cells driven by vascular risk factors associated with AD allows the passage of toxic substances to the cerebral parenchyma, producing chronic hypoperfusion that eventually causes an inflammatory and neurotoxic response. In this process, the levels of several biomarkers are disrupted, such as an increase in adhesion molecules that allow the passage of leukocytes to the cerebral parenchyma, increasing the permeability of the BBB; moreover, other vascular players, including endothelin-1, also mediate artery inflammation. As a consequence of the disruption of the BBB, a progressive neuroinflammatory response is produced that, added to the astrogliosis, eventually triggers neuronal degeneration (possibly responsible for cognitive deterioration). Recently, new molecules have been proposed as early biomarkers for endothelial dysfunction that can constitute new therapeutic targets as well as early diagnostic and prognostic markers for AD.
登录
查看更多内容
影响因子：
6.3
作者：
Anttila, K.;Streng, T.;Nikinmaa, M.
通讯作者：
Nikinmaa, M.
DOI：
10.3390/diagnostics11050740
发表时间：
2021-04-21
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Choi HI;Kim K;Lee J;Chang Y;Rhee HY;Park S;Lee WI;Choe W;Ryu CW;Jahng GH
通讯作者：
Jahng GH
影响因子：
4
作者：
Brundel, Manon;Heringa, Sophie M.;Biessels, Geert Jan
通讯作者：
Biessels, Geert Jan
DOI：
10.1186/s13195-018-0385-8
发表时间：
2018-06-23
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Chakraborty A;Chatterjee M;Twaalfhoven H;Del Campo Milan M;Teunissen CE;Scheltens P;Fontijn RD;van Der Flier WM;de Vries HE
通讯作者：
de Vries HE
DOI：
10.3233/jad-150400
发表时间：
2015
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Bilello M;Doshi J;Nabavizadeh SA;Toledo JB;Erus G;Xie SX;Trojanowski JQ;Han X;Davatzikos C
通讯作者：
Davatzikos C