Reduced prefrontal cortical gray matter volume in young adults exposed to harsh corporal punishment.
Reduced prefrontal cortical gray matter volume in young adults exposed to harsh corporal punishment.
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DOI：
10.1016/j.neuroimage.2009.03.005
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发表时间：
2009-08
期刊：
影响因子：
5.7
通讯作者：
Teicher MH
中科院分区：
文献类型：
--
作者：
Tomoda A;Suzuki H;Rabi K;Sheu YS;Polcari A;Teicher MH
童年时期的严厉体罚（HCP）是一种与抑郁、攻击性和成瘾行为相关的慢性发育压力源。暴露于性虐待等创伤性压力源与大脑结构的改变有关，但对于 HCP 的潜在神经生物学后果尚不清楚。本研究的目的是使用基于体素的形态测量 (VBM) 来调查 HCP 是否与灰质体积 (GMV) 的明显变化相关。对 1,455 名年轻人（18-25 岁）进行了筛查，确定了 23 名接触过 HCP 的人（持续时间至少 3 年，每年 12 次，经常涉及物体）和 22 名健康对照。使用西门子 3T trio 扫描仪获得高分辨率 T1 加权 MRI 数据集。右侧内侧额叶回（内侧前额叶皮层；MPFC，BA10）的 GMV 降低了 19.1%（P = 0.037，校正簇水平），左侧内侧额叶回（背外侧前额叶皮层；DLPFC，BA 9）的 GMV 降低了 14.5%（P = 0.015，未校正的簇水平），左侧额叶回的 GMV 降低了 16.9%。 HCP 受试者的右前扣带回 (BA 24)（P < 0.001，未校正簇水平）。这些确定区域的 GMV 与 WAIS-III 的表现智商之间存在显着相关性。让儿童接触严酷的 HCP 可能会对大脑发育轨迹产生不利影响。然而，也可以想象，前额皮质发育的差异可能会增加接触 HCP 的风险。
Harsh corporal punishment (HCP) during childhood is a chronic, developmental stressor associated with depression, aggression and addictive behaviors. Exposure to traumatic stressors, such as sexual abuse, is associated with alteration in brain structure, but nothing is known about the potential neurobiological consequences of HCP. The aim of this study was to investigate whether HCP was associated with discernible alterations in gray matter volume (GMV) using voxel-based morphometry (VBM). 1,455 young adults (18–25 years) were screened to identify 23 with exposure to HCP (minimum 3 years duration, 12 episodes per year, frequently involving objects) and 22 healthy controls. High-resolution T1-weighted MRI datasets were obtained using Siemens 3T trio scanner. GMV was reduced by 19.1% in the right medial frontal gyrus (medial prefrontal cortex; MPFC, BA10) (P = 0.037, corrected cluster level), by 14.5% in the left medial frontal gyrus (dorsolateral prefrontal cortex; DLPFC, BA 9) (P = 0.015, uncorrected cluster level) and by 16.9% in the right anterior cingulate gyrus (BA 24) (P < 0.001, uncorrected cluster level) of HCP subjects. There were significant correlations between GMV in these identified regions and performance IQ on the WAIS-III. Exposing children to harsh HCP may have detrimental effects on trajectories of brain development. However, it is also conceivable that differences in prefrontal cortical development may increase risk of exposure to HCP.
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影响因子：
--
作者：
Geuze, Elbert;Westenberg, Herman G. M.;Schmahl, Christian
通讯作者：
Schmahl, Christian
影响因子：
1.9
作者：
BERNSTEIN, EM;PUTNAM, FW
通讯作者：
PUTNAM, FW
DOI：
10.1001/archpedi.1997.02170450018003
发表时间：
1997-08-01
影响因子：
--
作者：
Gunnoe, ML;Mariner, CL
通讯作者：
Mariner, CL
影响因子：
2.6
作者：
Golden, CJ;White, L;McLane, D
通讯作者：
McLane, D
暴露于父母言语虐待的年轻人中白质异常的初步证据。
影响因子：
10.6
作者：
Choi, Jeewook;Jeong, Bumseok;Rohan, Michael L.;Polcari, Ann M.;Teicher, Martin H.
通讯作者：
Teicher, Martin H.