Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse.
Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse.
复制标题
暴露于父母言语虐待的年轻人中白质异常的初步证据。
DOI：
10.1016/j.biopsych.2008.06.022
复制
发表时间：
2009-02-01
影响因子：
10.6
通讯作者：
Teicher, Martin H.
中科院分区：
文献类型：
--
作者：
Choi, Jeewook;Jeong, Bumseok;Rohan, Michael L.;Polcari, Ann M.;Teicher, Martin H.
关键词：
暴露于父母言语虐待（PVA）的精神后遗症似乎是可比的非家庭性虐待和目睹家庭暴力。扩散张量成像（DTI）用于确定PVA是否与脑白色物质（WM）束完整性异常相关。1271名健康的年轻人接受了儿童期逆境暴露的筛查。收集了16名未经药物治疗的受试者（4名男性/12名女性，平均年龄21.9±2.4岁）和16名健康对照者（5名男性/11名女性，21.0±1.6岁）的DTI，这些受试者有高水平PVA暴露史，但没有其他形式的虐待。分数各向异性（FA）的组间差异，父母的教育和收入的协变，使用基于轨道的空间统计（TBSS）进行了评估，并与症状评分和言语智商。三个WM束区域具有显著减少的FA：（1）左侧上级颞回的弓状束，（2）左侧海马后尾的扣带束，和（3）左侧穹窿体。这些区域的FA与平均PVA评分（分别为rs=-0.701，P<0.001; rs=-0.801，P<0.001; rs=0.524，P=0.002）和母亲言语虐待水平密切相关。在各组中，区域1的FA与言语智商（rs=0.411，P=0.024）和言语理解指数（rs=0.437，P=0.016）相关。区域2的FA与抑郁（rs=-0.504）、分离（rs=-0.373）和“边缘系统易激惹”（rs= -0.602）的评分呈负相关。3区FA与躯体化（rs=-0.389）、焦虑（rs=-0.311）呈负相关。暴露于PVA可能与神经通路完整性的改变有关，并对语言发育和精神病理学产生影响。
Psychiatric sequelae of exposure to parental verbal abuse (PVA) appears to be comparable to that of non-familial sexual abuse and witnessing domestic violence. Diffusion Tensor Imaging (DTI) was used to ascertain whether PVA was associated with abnormalities in brain white matter (WM) tract integrity. 1271 healthy young adults were screened for exposure to childhood adversity. DTI was collected on 16 unmedicated subjects with history of high-level exposure to PVA but no other form of maltreatment (4M/12F, mean age 21.9±2.4 yrs), and 16 healthy controls (5M/11F, 21.0±1.6 yrs). Group differences in fractional anisotropy (FA), covaried by parental education and income, were assessed using Tract-Based Spatial Statistics (TBSS), and correlated with symptom ratings and verbal IQ. Three WM tract regions had significantly reduced FA: (1) arcuate fasciculus in left superior temporal gyrus, (2) cingulum bundle by the posterior tail of the left hippocampus, and (3) the left body of the fornix. FA in these areas were strongly associated with average PVA scores (rs=-0.701, P<0.001; rs=-0.801, P<0.001; rs=0.524, P=0.002, respectively), and levels of maternal verbal abuse. Across groups FA in region 1 correlated with verbal IQ (rs=0.411, P=0.024) and verbal comprehension index (rs=0.437, P=0.016). FA in region 2 was inversely associated with ratings of depression (rs=-0.504), dissociation (rs=-0.373) and ‘limbic irritability’ (rs= -0.602). FA in region 3 was inversely correlated with ratings of somatization (rs=-0.389) and anxiety (rs=-0.311). Exposure to PVA may be associated with alteration in the integrity of neural pathways with implications for language development and psychopathology.
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影响因子：
3.2
作者：
Kim, Seog Ju;Jeong, Do-Un;Lyoo, In Kyoon
通讯作者：
Lyoo, In Kyoon
影响因子：
4.8
作者：
Catani, Marco
通讯作者：
Catani, Marco
影响因子：
1.9
作者：
BERNSTEIN, EM;PUTNAM, FW
通讯作者：
PUTNAM, FW
DOI：
10.1097/00004583-199703000-00012
发表时间：
1997-03-01
影响因子：
13.3
作者：
Bernstein, DP;Ahluvalia, T;Handelsman, L
通讯作者：
Handelsman, L
影响因子：
56.9
作者：
Caspi, A;McClay, J;Poulton, R
通讯作者：
Poulton, R