Synaptic organization and ionic basis of on and off channels in mudpuppy retina. II. Chloride-dependent ganglion cell mechanisms.

Synaptic organization and ionic basis of on and off channels in mudpuppy retina. II. Chloride-dependent ganglion cell mechanisms.
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DOI:
10.1085/jgp.67.6.661
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发表时间:
1976-06
期刊:
The Journal of general physiology
影响因子:
--
通讯作者:
Dacheux RF
Dacheux RF
中科院分区:
其他
文献类型:
--
作者:
Miller RF;Dacheux RF

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灌注的mudpuppy眼杯中的细胞外神经节细胞记录显示,无氯(c-f)灌注液消除了中心细胞的中心和周围兴奋、偏离中心细胞的周围兴奋以及开-关细胞的开放电。神经节细胞感受野组织的这些变化是考虑到c-f环境对神经节细胞突触前神经元的影响而预期的。然而,氯依赖性抑制性突触后(IPS)反应已被观察到开关神经节细胞。这些抑制性突触后电位(IPSP)是由兴奋性突触后电位(ESPS)预触发的,并且显然是由无长突细胞介导的。关闭细胞的光激活超极化不是氯依赖性IPSP的结果,可能是由去易化引起的。
Extracellular ganglion cell recordings in the perfused mudpuppy eyecup show that a chloride-free (c-f) perfusate abolishes the center and surround excitation of on-center cells, the surround excitation of off- center cells, and the on discharge of on-off cells. These changes in ganglion cell receptive field organization are anticipated in view of the effects of a c-f environment on the neurons which are presynaptic to the ganglion cells. However, chloride-dependent inhibitory postsynaptic (IPS) responses have been observed in on-off ganglion cells. These inhibitory postsynaptic potentials (IPSP's) are preceeded by (ESPS's) exitatory postsynaptic potentials and are apparently mediated by amacrine cells. The light-activated hyperpolarization of off cells is not the result of a chloride-dependent IPSP and probably results from disfacilitation.
DOI: 10.1085/jgp.67.6.639
发表时间: 1976-06
期刊: The Journal of general physiology
影响因子: --
作者:
Miller RF;Dacheux RF
通讯作者: Dacheux RF
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MOTOKIZAWA, F;REUBEN, JP;GRUNDFEST, H
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