Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction.
Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction.
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DOI：
10.1186/1471-2261-13-12
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发表时间：
2013-02-28
影响因子：
2.1
通讯作者：
Erlinge D
中科院分区：
文献类型：
--
作者：
Gidlöf O;Smith JG;Miyazu K;Gilje P;Spencer A;Blomquist S;Erlinge D
在心肌梗死（MI）患者中，心肌富集的microRNA（miRNAs）水平增加。我们希望评估心脏富集的miRNAs在疑似急性冠状动脉综合征（ACS）患者中的诊断和预后潜力。采用真实的时间PCR检测了424例在冠心病监护室接受治疗的疑似ACS患者血浆样本中miR-1、miR-208 b和miR-499- 5 p的含量。评估了miRNAs对心肌梗死临床诊断的区分以及与30天死亡率和心力衰竭诊断的相关性。还评估了射血分数（LVEF）与左心室收缩功能障碍的相关性。为了确认心肌起源，在冠状动脉旁路手术期间测量miRNA。心肌梗死患者的miRNA水平较高，且与LVEF相关（p < 0.001）。对于miR-208 b（AUC = 0.82）和miR-499- 5 p（AUC = 0.79），MI的区分是准确的，但显著低于肌钙蛋白T（AUC = 0.95）。对于miR-208 b，增加的miRNA水平与30天内死亡或心力衰竭的风险增加密切相关（OR 1.79，95% CI = 1.38-2.23，p = 1 × 10-5）和miR-499-5p（OR 1.70，95% CI = 1.31-2.20，p = 5 × 10-5），但调整肌钙蛋白T后，相关性丧失。在手术过程中，心脏停搏-再灌注后，miR-208 b和miR-499- 5 p在冠状窦中的释放水平明显高于外周静脉。我们的研究结果证实了心肌梗死患者血液中富含心脏的miRNA水平的增加，并建立了心肌梗死后心脏收缩功能降低和死亡或心力衰竭风险的miRNA水平增加的相关性。
Increased levels of cardio-enriched microRNAs (miRNAs) have been described in patients with myocardial infarction (MI). We wanted to evaluate the diagnostic and prognostic potential of cardio-enriched miRNAs in patients presenting with a suspected acute coronary syndrome (ACS). Cardio-enriched miRNAs (miR-1, miR-208b and miR-499-5p) were measured using real time PCR in plasma samples from 424 patients with suspected ACS treated in a coronary care unit. miRNAs were assessed for discrimination of a clinical diagnosis of myocardial infarction and for association with 30-day mortality and diagnosis of heart failure. Correlation with left ventricular systolic dysfunction as measured by the ejection fraction (LVEF) was also assessed. To confirm myocardial origin miRNA was measured during coronary artery bypass surgery. miRNAs were higher in MI patients and correlated with LVEF (p < 0.001). Discrimination of MI was accurate for miR-208b (AUC = 0.82) and miR-499-5p (AUC = 0.79) but considerable lower than for Troponin T (AUC = 0.95). Increased miRNA levels were strongly associated with increased risk of mortality or heart failure within 30 days for miR-208b (OR 1.79, 95% CI = 1.38-2.23, p = 1 × 10-5) and miR-499-5p (OR 1.70, 95% CI = 1.31-2.20, p = 5 × 10-5) but the association was lost when adjusting for Troponin T. During surgery miR-208b and miR-499-5p was released in the coronary sinus after cardioplegia-reperfusion to markedly higher levels than in a peripheral vein. Our findings confirm increased levels of cardio-enriched miRNAs in the blood of MI patients and establish association of increased miRNA levels with reduced systolic function after MI and risk of death or heart failure.
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影响因子：
7.5
作者：
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通讯作者：
Olson EN
影响因子：
18.2
作者：
Goren, Yaron;Kushnir, Michal;Amir, Offer
通讯作者：
Amir, Offer
影响因子：
9.3
作者：
Adachi, Taichi;Nakanishi, Michio;Iwai, Naoharu
通讯作者：
Iwai, Naoharu
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DOI：
10.1007/s00392-011-0343-y
发表时间：
2011-12
期刊：
Clinical research in cardiology : official journal of the German Cardiac Society
影响因子：
--
作者：
Gu YL;Voors AA;Zijlstra F;Hillege HL;Struck J;Masson S;Vago T;Anker SD;van den Heuvel AF;van Veldhuisen DJ;de Smet BJ
通讯作者：
de Smet BJ
影响因子：
5
作者：
Widera, Christian;Gupta, Shashi K.;Thum, Thomas
通讯作者：
Thum, Thomas