A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects.
A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects.
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DOI：
10.1038/s41467-018-06504-7
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发表时间：
2018-10-25
影响因子：
16.6
通讯作者：
Duda GN
中科院分区：
文献类型：
--
作者：
Petersen A;Princ A;Korus G;Ellinghaus A;Leemhuis H;Herrera A;Klaumünzer A;Schreivogel S;Woloszyk A;Schmidt-Bleek K;Geissler S;Heschel I;Duda GN
开发用于治疗骨缺损的生物材料通常侧重于通过直接膜内骨化实现骨愈合。相比之下，我们身体中的大多数骨骼都是通过称为软骨内骨化的第二条途径从软骨模板发育而来的。尚未解决的临床挑战，再生大骨缺损带来了软骨内骨化作为骨愈合的替代方法的讨论。然而，缺乏通过软骨内骨化再生大骨缺损的生物材料策略。在这里，我们报告了一种具有通道状孔结构的生物材料，用于在愈合的早期阶段控制细胞募集和组织图案化。由于细胞外基质排列、CD 146+祖细胞积聚和血管化受限，在大鼠中诱导高度组织化的软骨内骨化过程。我们的研究结果表明，一个纯生物材料的方法有可能重演骨愈合的发育骨生长过程。这可能会激发未来的生物材料为基础的组织再生策略。缺乏一种生物工程方法来增强大骨缺损的再生。在这里，作者表明，具有通道样孔隙结构的生物材料支架能够通过定向细胞募集和细胞外基质排列实现有组织的软骨内成骨。
Biomaterials developed to treat bone defects have classically focused on bone healing via direct, intramembranous ossification. In contrast, most bones in our body develop from a cartilage template via a second pathway called endochondral ossification. The unsolved clinical challenge to regenerate large bone defects has brought endochondral ossification into discussion as an alternative approach for bone healing. However, a biomaterial strategy for the regeneration of large bone defects via endochondral ossification is missing. Here we report on a biomaterial with a channel-like pore architecture to control cell recruitment and tissue patterning in the early phase of healing. In consequence of extracellular matrix alignment, CD146+ progenitor cell accumulation and restrained vascularization, a highly organized endochondral ossification process is induced in rats. Our findings demonstrate that a pure biomaterial approach has the potential to recapitulate a developmental bone growth process for bone healing. This might motivate future strategies for biomaterial-based tissue regeneration. A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.
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影响因子：
4.1
作者：
Kuhn, Liisa T.;Liu, Yongxing;Goldberg, A. Jon
通讯作者：
Goldberg, A. Jon
影响因子：
3
作者：
Allen, DM;Mao, JJ
通讯作者：
Mao, JJ
DOI：
10.1073/pnas.192291499
发表时间：
2002-09-17
影响因子：
11.1
作者：
Alsberg, E;Anderson, KW;Mooney, DJ
通讯作者：
Mooney, DJ
影响因子：
4.1
作者：
Chakkalakal, DA;Strates, BS;McGuire, MH
通讯作者：
McGuire, MH
影响因子：
6.4
作者：
Gawlitta, Debby;Farrell, Eric;Dhert, Wouter J. A.
通讯作者：
Dhert, Wouter J. A.