Dietary energy density is associated with obesity and other biomarkers of chronic disease in US adults.
Dietary energy density is associated with obesity and other biomarkers of chronic disease in US adults.
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饮食能量密度与美国成年人的肥胖症和其他慢性疾病的生物标志物有关。
DOI：
10.1007/s00394-014-0685-0
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发表时间：
2015-02
影响因子：
5
通讯作者：
Hartman TJ
中科院分区：
文献类型：
--
作者：
Vernarelli JA;Mitchell DC;Rolls BJ;Hartman TJ
鉴于目前肥胖症的流行，确定可能有助于疾病预防的饮食因素非常重要。本研究的目的是评估能量密集饮食的消耗与慢性疾病的既定标记因素（包括体重和身体脂肪测量值）之间的关联。对参加 2005-2008 年国家健康和营养检查调查的 9,551 名 18 岁以上成年人的全国代表性样本的数据进行了分析。研究了膳食能量密度（ED，每份食物重量的能量，kcal/g）与肥胖标志物[包括体重指数（BMI）和腰围（WC）]、胰岛素不敏感[包括空腹血糖、胰岛素和胰岛素抵抗稳态评估模型（HOMA-IR）]以及炎症标志物之间的关联。在多变量模型中，饮食性 ED 与男性和女性肥胖呈正相关。总体而言，肥胖成年人的饮食 ED 显着高于瘦成年人 (p < 0.0001)。当前吸烟者的 ED 显着高于不吸烟者（2.00 vs. 1.75，p < 0.01），并且确定吸烟状况改变了女性 ED 与体重状况之间的关系（p 交互作用 0.03）。在两性中，BMI 和 ED 之间均呈正线性关系（p 趋势分别为 0.01 和 0.0002）；在调整相关辅助因子后，在女性中也观察到 WC 和 ED 之间的线性趋势（p 趋势<0.001）。在女性中，ED 与 HOMA-IR 和空腹胰岛素呈正相关；然而，这种关系在男性中并未观察到。在任何性别中均未观察到 ED 与 C 反应蛋白之间存在显着关联。这些发现支持最近的肥胖和疾病预防建议，即低 ED 饮食。
Given the current prevalence of obesity, it is important to identify dietary factors that may aid in disease prevention. The objective of the present study was to evaluate the association between consumption of an energy-dense diet and established markers factors for chronic disease, including body weight and measures of body fatness. Data from a nationally representative sample of 9,551 adults ≥18 years who participated in the 2005–2008 National Health and Nutrition Examination Survey were analyzed. The association between dietary energy density (ED, energy per weight of food, kcal/g) and markers for obesity [including body mass index (BMI) and waist circumference (WC)], insulin insensitivity [including fasting glucose, insulin and homeostasis assessment model for insulin resistance (HOMA-IR)], and markers for inflammation was examined. Dietary ED was positively associated with obesity in both men and women in multivariate models. Overall, obese adults had a significantly higher dietary ED than lean adults (p < 0.0001). Current smokers had significantly higher ED than non-smokers (2.00 vs. 1.75, p < 0.01), and it was determined that smoking status modified the relationship between ED and weight status in women (p interaction 0.03). In both sexes, there was a positive linear relationship between BMI and ED (p trend 0.01 and 0.0002, respectively); a linear trend between WC and ED was also observed in women (p trend<0.001) after adjusting for relevant cofactors. In women, ED was positively associated with HOMA-IR and fasting insulin; though, this relationship was not observed in men. No significant associations between ED and C-reactive protein were observed in either sex. These findings support recent obesity and disease prevention recommendations to consume a diet low in ED.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
16.2
作者：
Mendoza, Jason A.;Drewnowski, Adam;Christakis, Dimitri A.
通讯作者：
Christakis, Dimitri A.
影响因子：
4.2
作者：
Hartman, Terryl J.;Albert, Paul S.;Lanza, Elaine
通讯作者：
Lanza, Elaine
影响因子：
7.1
作者：
Ledikwe, Jenny H.;Blanck, Heidi M.;Rolls, Barbara J.
通讯作者：
Rolls, Barbara J.
影响因子：
--
作者：
Ledikwe, Jenny H.;Blanck, Heidi M.;Rolls, Barbara J.
通讯作者：
Rolls, Barbara J.