Synergistic interaction between baclofen administration into the median raphe nucleus and inconsequential visual stimuli on investigatory behavior of rats.
Synergistic interaction between baclofen administration into the median raphe nucleus and inconsequential visual stimuli on investigatory behavior of rats.
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DOI：
10.1007/s00213-011-2450-x
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发表时间：
2012-03
影响因子：
3.4
通讯作者：
Ikemoto, Satoshi
中科院分区：
文献类型：
--
作者：
Vollrath-Smith, Fiori R.;Shin, Rick;Ikemoto, Satoshi
关键词：
非偶然性管理安非他明到腹侧纹状体或全身尼古丁增加反应奖励的无关紧要的视觉刺激。当这些药物被偶然给予时，老鼠学会了自我管理。我们最近发现，大鼠自我管理的GABAB受体激动剂巴氯芬进入正中（MR）或背侧（DR）中缝核。我们研究了巴氯芬在MR或DR中的非偶然给药是否增加了闪光奖励的大鼠行为。权且呈现出一个闪光灯稍加杠杆的压力机。而非偶然的管理巴氯芬到MR或DR没有可靠地增加杠杆压力在没有视觉刺激奖励，同样的操作显着增加杠杆压力奖励的视觉刺激。腹腔注射安非他明（3毫克/公斤）引起的自发活动增加未能与视觉刺激的杠杆按压增加。这些结果表明，所观察到的视觉刺激寻求的增强不同于一般运动活动的增强。当巴氯芬与GABAB受体拮抗剂SCH 50911共同给药时，视觉刺激寻求减少，证实了局部GABAB受体的参与。当巴氯芬给药前腹腔注射多巴胺拮抗剂SCH 23390（0.025 mg/kg）时，寻求视觉刺激也减弱，这表明增强的视觉刺激寻求依赖于完整的多巴胺信号。巴氯芬给药到MR或DR增加视觉刺激诱导的回避行为。刺激MR和DR中的GABAB受体似乎解除了涉及刺激接近反应的动机过程。
Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABAB receptor agonist baclofen into the median (MR) or dorsal (DR) raphe nuclei. We examined whether noncontingent administration of baclofen into the MR or DR increases rats’ investigatory behavior rewarded by a flash of light. Contingent presentations of a flash of light slightly increased lever presses. Whereas noncontingent administration of baclofen into the MR or DR did not reliably increase lever presses in the absence of visual stimulus reward, the same manipulation markedly increased lever presses rewarded by the visual stimulus. Heightened locomotor activity induced by intraperitoneal injections of amphetamine (3 mg/kg) failed to concur with increased lever pressing for the visual stimulus. These results indicate that the observed enhancement of visual stimulus seeking is distinct from an enhancement of general locomotor activity. Visual stimulus seeking decreased when baclofen was co-administered with the GABAB receptor antagonist, SCH 50911, confirming the involvement of local GABAB receptors. Seeking for visual stimulus also abated when baclofen administration was preceded by intraperitoneal injections of the dopamine antagonist, SCH 23390 (0.025 mg/kg), suggesting enhanced visual stimulus seeking depends on intact dopamine signals. Baclofen administration into the MR or DR increased investigatory behavior induced by visual stimuli. Stimulation of GABAB receptors in the MR and DR appears to disinhibit the motivational process involving stimulus–approach responses.
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影响因子：
8.2
作者：
Ikemoto, Satoshi
通讯作者：
Ikemoto, Satoshi
影响因子：
3.4
作者：
FRAY, PJ;SAHAKIAN, BJ;IVERSEN, SD
通讯作者：
IVERSEN, SD
影响因子：
3
作者：
Ikemoto, S;Sharpe, LG
通讯作者：
Sharpe, LG
影响因子：
3.4
作者：
KELLEY, AE;WINNOCK, M;STINUS, L
通讯作者：
STINUS, L
影响因子：
3.4
作者：
Palmatier, M;Evans-Martin, FF;Sved, AF
通讯作者：
Sved, AF