Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies.
Potential confounding of particulate matter on the short-term association between ozone and mortality in multisite time-series studies.
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在多站点时间序列研究中，在臭氧与死亡率之间的短期关联上，颗粒物的潜在混淆。
DOI：
10.1289/ehp.10108
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发表时间：
2007-11
影响因子：
10.4
通讯作者：
Dominici, Francesca
中科院分区：
文献类型：
--
作者：
Bell, Michelle L.;Kim, Jee Young;Dominici, Francesca
关于短期暴露于臭氧和死亡率之间的关系的一个关键问题是，这种关系在多大程度上受到环境暴露于颗粒物的混淆。我们研究了空气动力学直径< 10和< 2.5 μm的颗粒物（PM10和PM2.5）是否是臭氧和死亡率关联的混杂因素，使用的数据来自1987年至2000年的98个美国城市社区。我们a）估计每日臭氧和每日PM浓度（按臭氧或PM水平分层）之间的相关性; B）将PM作为协变量纳入时间序列模型;以及c）将PM作为协变量纳入d），但仅考虑臭氧低于特定值的天数。数据的可得性阻碍了分析。在有PM10数据的93个社区中，只有25.0%的研究日有臭氧和PM10数据。在有PM2.5数据的91个社区中，研究期间只有9.2%的天数有臭氧和PM2.5数据。无论是PM措施是高度相关的臭氧在任何水平的臭氧或PM。臭氧对死亡率的短期影响的国家和社区特定影响估计值对于将PM10或PM2.5纳入时间序列模型是可靠的。使用子集方法，即使在低臭氧水平（< 10 ppb）下也保持稳健性。结果提供的证据表明，无论是PM10还是PM2.5都不是观察到的臭氧和死亡率关系的可能混淆因素。需要进一步研究臭氧对PM化学成分死亡率的短期影响的潜在混淆。
A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. We investigated whether particulate matter < 10 and < 2.5 μm in aerodynamic diameter (PM10 and PM2.5) is a confounder of the ozone and mortality association using data for 98 U.S. urban communities from 1987 to 2000. We a) estimated correlations between daily ozone and daily PM concentrations stratified by ozone or PM levels; b) included PM as a covariate in time-series models; and c) included PM as a covariate as in d), but within a subset approach considering only days with ozone below a specified value. Analysis was hindered by data availability. In the 93 communities with PM10 data, only 25.0% of study days had data on both ozone and PM10. In the 91 communities with PM2.5 data, only 9.2% of days in the study period had data on ozone and PM2.5. Neither PM measure was highly correlated with ozone at any level of ozone or PM. National and community-specific effect estimates of the short-term effects of ozone on mortality were robust to inclusion of PM10 or PM2.5 in time-series models. The robustness remains even at low ozone levels (< 10 ppb) using a subset approach. Results provide evidence that neither PM10 nor PM2.5 is a likely confounder of observed ozone and mortality relationships. Further investigation is needed to investigate potential confounding of the short-term effects of ozone on mortality by PM chemical composition.
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影响因子：
105.7
作者：
Katsouyanni, K;Touloumi, G;Anderson, HR
通讯作者：
Anderson, HR
影响因子：
120.7
作者：
Dominici, F;Peng, RD;Samet, JM
通讯作者：
Samet, JM
影响因子：
11.8
作者：
Kan, Haidong;London, Stephanie J.;Chen, Bingheng
通讯作者：
Chen, Bingheng
DOI：
10.1038/sj.jea.7500169
发表时间：
2001-07-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Thurston, GD;Ito, K
通讯作者：
Ito, K
DOI：
10.1164/rccm.200403-333oc
发表时间：
2004-11-15
影响因子：
24.7
作者：
Gryparis, A;Forsberg, B;Dörtbudak, Z
通讯作者：
Dörtbudak, Z