Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.
Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.
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DOI:
10.1002/alz.12626
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发表时间:
2023-01
影响因子:
14
通讯作者:
Kaplan, Hillard
中科院分区:
文献类型:
--
作者:
Gatz, Margaret;Mack, Wendy J.;Chui, Helena C.;Law, E. Meng;Barisano, Giuseppe;Sutherland, M. Linda;Sutherland, James D.;Rodriguez, Daniel Eid;Gutierrez, Raul Quispe;Adrian, Juan Copajira;Cuata, Jesus Bani;Borenstein, Amy R.;Walters, Ellen E.;Irimia, Andrei;Rowan, Christopher J.;Wann, L. Samuel;Allam, Adel H.;Thompson, Randall C.;Miyamoto, Michael, I;Michalik, David E.;Cummings, Daniel K.;Seabright, Edmond;Garcia, Angela R.;Hooper, Paul L.;Kraft, Thomas S.;Finch, Caleb E.;Thomas, Gregory S.;Stieglitz, Jonathan;Trumble, Benjamin C.;Gurven, Michael D.;Kaplan, Hillard
We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Participants from population‐based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini‐Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age‐standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non‐Alzheimer's disease (AD) dementia phenotype.
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影响因子:
168.9
作者:
Kaplan, Hillard;Thompson, Randall C.;Thomas, Gregory S.
通讯作者:
Thomas, Gregory S.
影响因子:
7.1
作者:
Kraft, Thomas S.;Stieglitz, Jonathan;Gurven, Michael
通讯作者:
Gurven, Michael
DOI:
10.1017/s135561770505071x
发表时间:
2005-09-01
影响因子:
2.6
作者:
Baiyewu, O;Unverzagt, FW;Hendrie, HC
通讯作者:
Hendrie, HC
影响因子:
48
作者:
Barnes, Deborah E.;Yaffe, Kristine
通讯作者:
Yaffe, Kristine
影响因子:
4
作者:
GANGULI, M;RATCLIFF, G;DEKOSKY, S
通讯作者:
DEKOSKY, S