Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.

Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.
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DOI:
10.1002/alz.12626
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发表时间:
2023-01
影响因子:
14
通讯作者:
Kaplan, Hillard
Kaplan, Hillard
中科院分区:
医学1区
文献类型:
--
作者:
Gatz, Margaret;Mack, Wendy J.;Chui, Helena C.;Law, E. Meng;Barisano, Giuseppe;Sutherland, M. Linda;Sutherland, James D.;Rodriguez, Daniel Eid;Gutierrez, Raul Quispe;Adrian, Juan Copajira;Cuata, Jesus Bani;Borenstein, Amy R.;Walters, Ellen E.;Irimia, Andrei;Rowan, Christopher J.;Wann, L. Samuel;Allam, Adel H.;Thompson, Randall C.;Miyamoto, Michael, I;Michalik, David E.;Cummings, Daniel K.;Seabright, Edmond;Garcia, Angela R.;Hooper, Paul L.;Kraft, Thomas S.;Finch, Caleb E.;Thomas, Gregory S.;Stieglitz, Jonathan;Trumble, Benjamin C.;Gurven, Michael D.;Kaplan, Hillard

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我们评估了过着自给自足生活方式的土著提斯曼 (Tsimane) 和莫塞滕 (Moseten) 的痴呆症和轻度认知障碍 (MCI) 患病率。使用改良版简易精神状态检查、知情者访谈、纵向认知测试和脑计算机断层扫描 (CT) 扫描对来自 60 岁以上人口样本的参与者 (n = 623) 进行评估。 Tsimane 表现出 5 例痴呆症(n = 435;粗患病率 = 1.2%,95% 置信区间 [CI]:0.4,2.7); Moseten 展示了 1 例病例(n = 169;粗患病率 = 0.6%,95% CI:0.0, 3.2),所有年龄均≥ 80 岁。 Tsimane 的年龄标准化 MCI 患病率为 7.7% (95% CI: 5.2, 10.3),Moseten 的年龄标准化 MCI 患病率为 9.8% (95% CI: 4.9, 14.6)。认知障碍与视觉空间障碍、帕金森症状和基底神经节血管钙化有关。该人群的痴呆症患病率是世界上最低的。广泛的颅内内侧动脉钙化提示以前未被识别的非阿尔茨海默病(AD)痴呆表型。
We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Participants from population‐based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini‐Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age‐standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non‐Alzheimer's disease (AD) dementia phenotype.
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