Assessing toxicant emissions from e-liquids with DIY additives used in response to a potential flavour ban in e-cigarettes.
Assessing toxicant emissions from e-liquids with DIY additives used in response to a potential flavour ban in e-cigarettes.
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DOI：
10.1136/tc-2022-057505
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发表时间：
2022-11
期刊：
影响因子：
5.2
通讯作者：
Shihadeh, Alan
中科院分区：
文献类型：
--
作者：
El-Hellani, Ahmad;Soule, Eric K.;Daoud, Mohammad;Salman, Rola;El Hage, Rachel;Ardati, Ola;El-Kaassamani, Malak;Yassine, Amira;Karaoghlanian, Nareg;Talih, Soha;Saliba, Najat;Shihadeh, Alan
电子香烟（e-cigarettes）将含有尼古丁、丙二醇、甘油和诱人香味的液体雾化。在美国，法规限制了基于豆荚的系统中调味电子烟的可用性，预计将进一步收紧。作为回应，一些电子烟用户可能会尝试制作他们的电子液体（自己动手，DIY）。这项研究检查了几种雾化DIY电子液体的有毒物质排放。DIY添加剂是通过审查用户对假设的味道禁令、电子烟互联网论坛和DIY混合互联网网站的反应来确定的。它们包括精油、大麻二酚、三氯蔗糖和乙基麦芽酚。制备了具有不同浓度和添加剂与烟草和薄荷醇香料的组合的电子液体，并用于评估机器产生的气溶胶中的活性氧（ROS）、羰基和苯酚排放。数据显示，在无味、薄荷味或烟草味的电子液体中添加DIY添加剂，会使有毒物质的排放量增加到与商业风味电子液体相当的水平。电子液体中不同的添加剂浓度对测试的排放没有一致的显著影响，但是对于相同的添加剂浓度，增加功率产生显著更高的ROS、羰基和苯酚排放。将尼古丁添加到具有三氯蔗糖的DIY电子液体中产生了一些排放的增加和其他排放的减少，其中含有游离碱尼古丁的电子液体比含有尼古丁盐的电子液体产生更高的ROS排放。这项研究表明，DIY添加剂会影响电子烟的气溶胶有毒物质排放，政策制定者在限制市售调味电子烟液时应予以考虑。
Electronic cigarettes (e-cigarettes) aerosolise liquids that contain nicotine, propylene glycol, glycerol and appealing flavours. In the USA, regulations have limited the availability of flavoured e-cigarettes in pod-based systems, and further tightening is expected. In response, some e-cigarette users may attempt to make their e-liquids (do-it-yourself, DIY). This study examined toxicant emissions from several aerosolised DIY e-liquids. DIY additives were identified by reviewing users’ responses to a hypothetical flavour ban, e-cigarette internet forums and DIY mixing internet websites. They include essential oils, cannabidiol, sucralose and ethyl maltol. E-liquids with varying concentrations and combinations of additives and tobacco and menthol flavours were prepared and were used to assess reactive oxygen species (ROS), carbonyl and phenol emissions in machine-generated aerosols. Data showed that adding DIY additives to unflavoured, menthol-flavoured or tobacco-flavoured e-liquids increases toxicant emissions to levels comparable with those from commercial flavoured e-liquids. Varying additive concentrations in e-liquids did not have a consistently significant effect on the tested emissions, yet increasing power yielded significantly higher ROS, carbonyl and phenol emissions for the same additive concentration. Adding nicotine to DIY e-liquids with sucralose yielded increase in some emissions and decrease in others, with freebase nicotine-containing e-liquid giving higher ROS emissions than that with nicotine salt. This study showed that DIY additives can impact aerosol toxicant emissions from e-cigarettes and should be considered by policymakers when restricting commercially available flavoured e-liquids.
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影响因子：
4.6
作者：
Baker AN;Wilson SJ;Hayes JE
通讯作者：
Hayes JE
影响因子：
4.7
作者：
Kong, Grace;Morean, Meghan E.;Krishnan-Sarin, Suchitra
通讯作者：
Krishnan-Sarin, Suchitra
影响因子：
3.7
作者：
Morean, Meghan E.;Butler, Ellyn R.;Krishnan-Sarin, Suchitra
通讯作者：
Krishnan-Sarin, Suchitra
影响因子：
4.1
作者：
Son, Yeongkwon;Mishin, Vladimir;Meng, Qingyu
通讯作者：
Meng, Qingyu
影响因子：
5.2
作者：
El-Hage, Rachel;El-Hellani, Ahmad;Haddad, Christina;Salman, Rola;Talih, Soha;Shihadeh, Alan;Eissenberg, Thomas;Saliba, Najat Aoun
通讯作者：
Saliba, Najat Aoun