Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications.
Placental Immune Tolerance and Organ Transplantation: Underlying Interconnections and Clinical Implications.
复制标题
胎盘免疫耐受性和器官移植：潜在的互连和临床意义。
DOI：
10.3389/fimmu.2021.705950
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发表时间：
2021
影响因子：
7.3
通讯作者：
Ji J
中科院分区：
文献类型：
--
作者：
Sun JY;Wu R;Xu J;Xue HY;Lu XJ;Ji J
免疫系统识别并攻击非自身抗原，构成了抗感染免疫活性的基石。然而，在器官移植过程中，免疫系统也会攻击移植器官，导致免疫排斥和移植失败。有趣的是，尽管胚胎和胎盘是半同种异体移植物，就像移植的器官一样，它们可以诱导母体耐受，并且没有强烈的免疫反应。此外，胚胎或胎盘相关抗体可能会对随后的器官移植产生不利影响，尽管怀孕期间存在免疫耐受。因此，母胎界面的免疫耐受与正常感染防御之间的平衡为改善移植结局提供了可能的脱敏和耐受策略。近年来，人们对母胎免疫耐受与器官移植的关系进行了一些机制和临床应用方面的研究。然而，到目前为止，母胎免疫耐受的机制仍不清楚。本文综述了目前对母胎界面免疫耐受机制的认识，总结了免疫耐受与器官移植之间的相互关系，并描述了妊娠期同种免疫对器官移植的不良影响。
The immune system recognizes and attacks non-self antigens, making up the cornerstone of immunity activity against infection. However, during organ transplantation, the immune system also attacks transplanted organs and leads to immune rejection and transplantation failure. Interestingly, although the embryo and placenta are semi-allografts, like transplanted organs, they can induce maternal tolerance and be free of a vigorous immune response. Also, embryo or placenta-related antibodies might adversely affect subsequent organ transplantation despite the immune tolerance during pregnancy. Therefore, the balance between the immune tolerance in maternal-fetal interface and normal infection defense provides a possible desensitization and tolerance strategy to improve transplantation outcomes. A few studies on mechanisms and clinical applications have been performed to explore the relationship between maternal-fetal immune tolerance and organ transplantation. However, up to now, the mechanisms underlying maternal-fetal immune tolerance remain vague. In this review, we provide an overview on the current understanding of immune tolerance mechanisms underlying the maternal-fetal interface, summarize the interconnection between immune tolerance and organ transplantation, and describe the adverse effect of pregnancy alloimmunization on organ transplantation.
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影响因子：
7.3
作者：
Djurisic S;Hviid TV
通讯作者：
Hviid TV
T细胞共刺激和共抑制的分子机制。
DOI：
10.1038/nri3405
发表时间：
2013-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.1617927114
发表时间：
2016-12-27
影响因子：
11.1
作者：
Crespo, Angela C.;Strominger, Jack L.;Tilburgs, Tamara
通讯作者：
Tilburgs, Tamara
影响因子：
4.8
作者：
Ajith, Ashwin;Portik-Dobos, Vera;Horuzsko, Anatolij
通讯作者：
Horuzsko, Anatolij
影响因子：
3.4
作者：
Crespo ÂC;van der Zwan A;Ramalho-Santos J;Strominger JL;Tilburgs T
通讯作者：
Tilburgs T