Viral dynamics of acute HIV-1 infection.
Viral dynamics of acute HIV-1 infection.
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DOI：
10.1084/jem.190.6.841
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发表时间：
1999-09-20
期刊：
影响因子：
--
通讯作者：
Havlir DV
中科院分区：
文献类型：
--
作者：
Little SJ;McLean AR;Spina CA;Richman DD;Havlir DV
对8名急性HIV感染患者的病毒动力学进行了深入研究，以确定开始抗逆转录病毒治疗前后血浆HIV RNA的最早变化率。我们首次报道了基本繁殖数(R0)的估计，即当目标细胞没有耗尽时，感染细胞的后代在其生命周期中感染的细胞数量。平均初始病毒倍增时间为10h，病毒血症的高峰出现在报告的HIV暴露后21d。自发性下降率(α)在不同个体之间差异很大。在急性艾滋病毒感染期间开始有效的抗逆转录病毒治疗的受试者的第一阶段病毒衰减率(δi=0.3/天)与接受治疗的慢性艾滋病毒感染受试者的估计相似。停止抗逆转录病毒治疗的两名受试者的加倍时间几乎是急性感染期间的五倍。原发HIV感染对数生长期的平均基本繁殖数(R0)为19.3，这表明在没有耐药性或病毒潜伏的情况下，需要至少95%有效的疫苗或暴露后预防措施来消灭生产性病毒感染。这些测量为疫苗和其他策略的比较提供了基础，并支持了急性艾滋病毒感染的猴免疫缺陷病毒猕猴模型的有效性。
Viral dynamics were intensively investigated in eight patients with acute HIV infection to define the earliest rates of change in plasma HIV RNA before and after the start of antiretroviral therapy. We report the first estimates of the basic reproductive number (R 0), the number of cells infected by the progeny of an infected cell during its lifetime when target cells are not depleted. The mean initial viral doubling time was 10 h, and the peak of viremia occurred 21 d after reported HIV exposure. The spontaneous rate of decline (α) was highly variable among individuals. The phase 1 viral decay rate (δI = 0.3/day) in subjects initiating potent antiretroviral therapy during acute HIV infection was similar to estimates from treated subjects with chronic HIV infection. The doubling time in two subjects who discontinued antiretroviral therapy was almost five times slower than during acute infection. The mean basic reproductive number (R 0) of 19.3 during the logarithmic growth phase of primary HIV infection suggested that a vaccine or postexposure prophylaxis of at least 95% efficacy would be needed to extinguish productive viral infection in the absence of drug resistance or viral latency. These measurements provide a basis for comparison of vaccine and other strategies and support the validity of the simian immunodeficiency virus macaque model of acute HIV infection.
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影响因子：
39.2
作者：
MELLORS, JW;KINGSLEY, LA;GUPTA, P
通讯作者：
GUPTA, P
影响因子：
6.4
作者：
Imrie, A;Beveridge, A;Cooper, DA
通讯作者：
Cooper, DA
影响因子：
3.8
作者：
Notermans, DW;Goudsmit, J;Mittler, J
通讯作者：
Mittler, J
影响因子：
56.9
作者：
Perelson, AS;Neumann, AU;Ho, DD
通讯作者：
Ho, DD
影响因子：
158.5
作者：
CLARK, SJ;SAAG, MS;SHAW, GM
通讯作者：
SHAW, GM