Geometric Perfusion Deficits: A Novel OCT Angiography Biomarker for Diabetic Retinopathy Based on Oxygen Diffusion.
Geometric Perfusion Deficits: A Novel OCT Angiography Biomarker for Diabetic Retinopathy Based on Oxygen Diffusion.
复制标题
几何灌注缺陷：一种基于氧扩散的糖尿病视网膜病变的新型OCT血管造影生物标志物。
DOI：
10.1016/j.ajo.2020.09.007
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发表时间：
2021-03
影响因子：
4.2
通讯作者：
Fujimoto JG
中科院分区：
文献类型：
--
作者：
Chen S;Moult EM;Zangwill LM;Weinreb RN;Fujimoto JG
建立基于氧扩散的光学相干断层血管成像(OCTA)生物标志物几何灌注缺陷(GPD)，并评价其在健康受试者和糖尿病视网膜病变(DR)患者的初步研究中的应用。回顾性横断面研究。使用商用光谱域光学相干断层血管成像(OCTA)设备分别获得重复的3×3 mm~2和6×6 mm~2运动校正黄斑OCTA体积。通过自动分割获得与浅毛细血管丛(SCP)、深毛细血管丛(DCP)和全视网膜投射相对应的面部OCTA图像。对于每个投影，计算GPD百分比和血管密度百分比，作为对照指标，并将其值在正常眼和DR眼之间进行比较。重复的OCTA采集用于评估GPD和血管密度百分比的重测重复性。对15只正常眼和12只DR眼进行重复OCTA扫描。在所有EN脸投影中，DR眼的GPD百分比显著高于正常眼；血管密度百分比在除1个投影(DCP)外的所有投影眼中均显著降低。使用较大的GPD区域来确定局灶性血流灌注不足。重测分析显示，在大多数情况下，GPD百分比重复性优于血管密度百分比。GPD百分率与血管密度百分率呈显著负相关。几何灌注缺陷是一种基于氧扩散的OCTA生物标志物，它为黄斑微血管重构提供了一个定量的指标，具有强大的生理基础。GPD百分率可作为检测和监测DR的有用生物标志物。
To develop geometric perfusion deficits (GPD), an optical coherence tomography angiography (OCTA) biomarker based on oxygen diffusion, and to evaluate its utility in a pilot study of healthy subjects and patients with diabetic retinopathy (DR). Retrospective cross-sectional study. Commercial spectral-domain optical coherence tomography angiography (OCTA) instruments were used to acquire repeated 3 × 3-mm2 and 6 × 6-mm2 motion-corrected macular OCTA volumes. En face OCTA images corresponding to the superficial capillary plexus (SCP), deep capillary plexus (DCP), and full retinal projections were obtained using automatic segmentation. For each projection, the GPD percentage and the vessel density percentage, the control metric, were computed, and their values were compared between the normal and DR eyes. The repeated OCTA acquisitions were used to assess the test-retest repeatability of the GPD and vessel density percentages. Repeated OCTA scans of 15 normal eyes and 12 DR eyes were obtained. For all en face projections, GPD percentages were significantly higher in DR eyes than in normal eyes; vessel density percentages were significantly lower in all but 1 projection (DCP). Large GPD areas were used to identify focal perfusion deficits. Test-retest analysis showed that the GPD percentage had superior repeatability than the vessel density percentage in most cases. A strong negative correlation between the GPD percentage and the vessel density percentage was also found. Geometric perfusion deficits, an OCTA biomarker based on oxygen diffusion, provides a quantitative metric of macular microvascular remodeling with a strong physiological underpinning. The GPD percentage may serve as a useful biomarker for detecting and monitoring DR.
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