Neonatal brain metabolite concentrations: an in vivo magnetic resonance spectroscopy study with a clinical MR system at 3 Tesla.
Neonatal brain metabolite concentrations: an in vivo magnetic resonance spectroscopy study with a clinical MR system at 3 Tesla.
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DOI：
10.1371/journal.pone.0082746
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Obata T
中科院分区：
文献类型：
--
作者：
Tomiyasu M;Aida N;Endo M;Shibasaki J;Nozawa K;Shimizu E;Tsuji H;Obata T
脑代谢物浓度在整个发育过程中动态变化，特别是在幼儿期。本研究的目的是调查脑代谢物浓度的新生儿（孕后年龄（PCA）：30至43周）使用单体素磁共振波谱（MRS），并讨论之间的关系，这些代谢物的浓度变化和脑发育在新生儿期。使用以下标准共纳入83例新生儿受试者：新生儿必须无放射学异常、器质性疾病和神经系统症状; MR光谱必须具有≥ 4的信噪比;估计的代谢物浓度必须显示≤ 30%的Cramér-Rao下限。从基底节（BG）、半卵圆中心（CS）和小脑采集MRS数据（回波时间/重复时间，30/5000 ms; 3 T）。测定了5种代谢物的浓度：肌酸、胆碱、N-乙酰天冬氨酸、肌醇和谷氨酸/谷氨酰胺复合物（Glx）。获得了184个MR谱（83个BG、77个CS和24个小脑谱）。肌酸、N-乙酰天冬氨酸和Glx在PCA中的浓度增加。胆碱与PCA在任何地区都不相关。至于肌醇，其浓度降低与PCA在BG中，而增加与PCA在小脑中。定量脑代谢物浓度及其在新生儿期的变化进行了评估。虽然观察到的变化部分类似于以前的报告中检测到的，我们的结果是更多的受试者（n = 83），和更高的磁场（3 T）。本研究中检测的代谢物浓度及其变化是临床上有用的新生儿脑发育指标。
Brain metabolite concentrations change dynamically throughout development, especially during early childhood. The purpose of this study was to investigate the brain metabolite concentrations of neonates (postconceptional age (PCA): 30 to 43 weeks) using single-voxel magnetic resonance spectroscopy (MRS) and to discuss the relationships between the changes in the concentrations of such metabolites and brain development during the neonatal period. A total of 83 neonatal subjects were included using the following criteria: the neonates had to be free of radiological abnormalities, organic illness, and neurological symptoms; the MR spectra had to have signal-to-noise ratios ≥ 4; and the estimated metabolite concentrations had to display Cramér-Rao lower bounds of ≤ 30%. MRS data (echo time/repetition time, 30/5000 ms; 3T) were acquired from the basal ganglia (BG), centrum semiovale (CS), and the cerebellum. The concentrations of five metabolites were measured: creatine, choline, N-acetylaspartate, myo-inositol, and glutamate/glutamine complex (Glx). One hundred and eighty-four MR spectra were obtained (83 BG, 77 CS, and 24 cerebellum spectra). Creatine, N-acetylaspartate, and Glx displayed increases in their concentrations with PCA. Choline was not correlated with PCA in any region. As for myo-inositol, its concentration decreased with PCA in the BG, whereas it increased with PCA in the cerebellum. Quantitative brain metabolite concentrations and their changes during the neonatal period were assessed. Although the observed changes were partly similar to those detected in previous reports, our results are with more subjects (n = 83), and higher magnetic field (3T). The metabolite concentrations examined in this study and their changes are clinically useful indices of neonatal brain development.
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影响因子：
3.3
作者：
Kreis, R;Hofmann, L;Hüppi, PS
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Hüppi, PS
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作者：
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