Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing.
Shared and unique neural circuitry underlying temporally unpredictable threat and reward processing.
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共享的和独特的神经回路潜在的时间不可预测的威胁和奖励处理。
DOI：
10.1093/scan/nsab006
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发表时间：
2021-03-24
影响因子：
4.2
通讯作者：
Gorka SM
中科院分区：
文献类型：
--
作者：
Radoman M;Lieberman L;Jimmy J;Gorka SM
时间上不可预测的刺激会影响跨物种的行为，正如之前在固定或可变开始的简单威胁和奖励序列中所证明的那样。神经成像研究已经确定了一个特定的额叶神经回路，在预期暂时不可预测的威胁（u -威胁）时可能会参与其中。然而，时间不可预知奖励（U-reward）处理的神经机制尚不完全清楚。目前还不清楚这些过程是由重叠的还是不同的神经系统介导的。鉴于这些神经系统的破坏可能导致对不确定性的不适应反应，这些知识差距值得注意。本研究利用159名年轻人的功能性磁共振成像数据，我们发现，对u -威胁和u -奖励的预期都会引发右侧前岛、丘脑右侧腹前核和右侧额下回的激活。相对于u -奖励，u -威胁也激活了右侧后岛和背前扣带皮层。相比之下，相对于u -威胁，u -奖励激发了右侧梭状回和左侧枕中回的激活。尽管在预测u -威胁和u -奖励的神经回路中有一些重叠，但这些过程似乎主要由不同的回路介导。需要进一步的研究来证实和扩展这些初步发现。
Temporally unpredictable stimuli influence behavior across species, as previously demonstrated for sequences of simple threats and rewards with fixed or variable onset. Neuroimaging studies have identified a specific frontolimbic circuit that may become engaged during the anticipation of temporally unpredictable threat (U-threat). However, the neural mechanisms underlying processing of temporally unpredictable reward (U-reward) are incompletely understood. It is also unclear whether these processes are mediated by overlapping or distinct neural systems. These knowledge gaps are noteworthy given that disruptions within these neural systems may lead to maladaptive response to uncertainty. Here, using functional magnetic resonance imaging data from a sample of 159 young adults, we showed that anticipation of both U-threat and U-reward elicited activation in the right anterior insula, right ventral anterior nucleus of the thalamus and right inferior frontal gyrus. U-threat also activated the right posterior insula and dorsal anterior cingulate cortex, relative to U-reward. In contrast, U-reward elicited activation in the right fusiform and left middle occipital gyrus, relative to U-threat. Although there is some overlap in the neural circuitry underlying anticipation of U-threat and U-reward, these processes appear to be largely mediated by distinct circuits. Future studies are needed to corroborate and extend these preliminary findings.
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