Continuous electrical current and zinc sulphate administered by transdermal iontophoresis improves skin healing in diabetic rats induced by alloxan: morphological and ultrastructural analysis.
Continuous electrical current and zinc sulphate administered by transdermal iontophoresis improves skin healing in diabetic rats induced by alloxan: morphological and ultrastructural analysis.
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DOI：
10.1155/2014/980232
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发表时间：
2014
影响因子：
4.3
通讯作者：
Spadella CT
中科院分区：
文献类型：
--
作者：
Langoni Cassettari L;Colli Rocha Dias P;Natália Lucchesi A;Ferraz de Arruda M;Veruska Paiva Ortolan E;Marques ME;Spadella CT
目的。评价连续电流（CEC）或锌经皮离子透入（Zn+TDI）的效果。方法：120只雄性Wistar大鼠经腹前区切口手术，分为6个实验组，每组40只：糖尿病组3只，正常组3只，分别给予CEC和Zn + TDI治疗。每组再分为4个亚组，每组10只，分别于术后第4、7、14、21天进行评估。在每个时期，对动物的临床和实验室参数进行分析。结果。光学显微镜和扫描电镜分析显示，在实验的各个阶段，未经治疗的糖尿病大鼠伤口愈合阶段延迟；与其他组相比，未经治疗的糖尿病大鼠皮肤疤痕的断裂强度（BS）显著降低。相比之下，非糖尿病组和经锌+ TDI治疗的糖尿病大鼠皮肤疤痕BS均显著增加，且未出现延迟愈合。结论。TDI单独或联合使用锌对外科伤口进行电刺激，能够持续改善糖尿病动物愈合过程中观察到的形态学和超微结构变化。
Purpose. Evaluated the effects of continuous electrical current (CEC) or zinc administrated by transdermal iontophoresis (Zn+TDI). Methods. 120 male Wistar rats were submitted to an incision surgery at the anterior region of abdomen and distributed into 6 experimental groups with 40 animals: 3 diabetic groups and 3 normal groups, untreated and treated with CEC alone or with Zn + TDI. Each group was further divided into 4 subgroups with 10 rats each to be evaluated on the 4th, 7th, 14th, and 21st day after surgery. In each period, clinical and laboratory parameters from the animals were analyzed. Results. The analysis by optical and scanning electron microscopy showed a delay in the phases of wound healing in diabetic rats without treatment in all periods of the experiment; breaking strength (BS) was significantly reduced in skin scars of untreated diabetic rats when compared to other groups. In contrast, BS in skin scars of nondiabetic groups and diabetic rats treated with Zn + TDI showed significant increase in those, besides not presenting delayed healing. Conclusion. Electrical stimulation of surgical wounds used alone or in association with zinc by TDI is able to consistently improve the morphological and ultrastructural changes observed in the healing of diabetic animals.
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影响因子：
56.9
作者：
MUSTOE, TA;PIERCE, GF;DEUEL, TF
通讯作者：
DEUEL, TF
影响因子：
4
作者：
Inpanya, Paichit;Faikrua, Atchariya;Viyoch, Jarupa
通讯作者：
Viyoch, Jarupa
影响因子：
6.5
作者：
Lee, PY;Chesnoy, S;Huang, L
通讯作者：
Huang, L
DOI：
10.1590/s0102-86502014000200008
发表时间：
2014-02-01
期刊：
Acta Cirúrgica Brasileira
影响因子：
--
作者：
Minossi, José Guilherme;Lima, Flávio de Oliveira;Spadella, César Tadeu
通讯作者：
Spadella, César Tadeu
影响因子：
7.7
作者：
Nathan DM;Bayless M;Cleary P;Genuth S;Gubitosi-Klug R;Lachin JM;Lorenzi G;Zinman B;DCCT/EDIC Research Group
通讯作者：
DCCT/EDIC Research Group