Frontal lobe γ-aminobutyric acid levels during adolescence: associations with impulsivity and response inhibition.
Frontal lobe γ-aminobutyric acid levels during adolescence: associations with impulsivity and response inhibition.
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DOI：
10.1016/j.biopsych.2013.01.033
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发表时间：
2013-08-15
影响因子：
10.6
通讯作者：
Jensen, J. Eric
中科院分区：
文献类型：
--
作者：
Silveri, Marisa M.;Sneider, Jennifer T.;Crowley, David J.;Covell, Michael J.;Acharya, Deepa;Rosso, Isabelle M.;Jensen, J. Eric
The brain undergoes major remodeling during adolescence, resulting in improved cognitive control and decision-making, and reduced impulsivity, components of behavior mediated in part by the maturing frontal lobe. Gamma-amino butyric acid (GABA), the main inhibitory neurotransmitter system, also matures during adolescence, with frontal lobe GABA receptors reaching adult levels late in adolescence. Thus, the objective of this study was to characterize in vivo developmental differences in brain GABA levels. Proton magnetic resonance spectroscopy (MRS) was employed at 4 Tesla to acquire metabolite data from the anterior cingulate cortex (ACC) and the parieto-occipital (POC) cortex in adolescents (n=30) and emerging adults (n=20). ACC GABA/Cr levels were significantly lower in adolescents relative to emerging adults, whereas no age differences were observed in the POC. Lower ACC GABA/Cr levels were significantly associated with greater impulsivity and worse response inhibition, with relationships being most pronounced for ACC GABA/Cr and No-Go response inhibition in adolescent males. These data provide the first human developmental in vivo evidence confirming frontal lobe GABA maturation, which was linked to impulsiveness and cognitive control. These findings suggest that reduced GABA may be an important neurobiological mechanism in the immature adolescent brain, contributing to the reduced, yet rapidly developing, ability to inhibit risky behaviors and to make decisions, which could compromise adolescent health and safety.
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DOI：
10.1016/j.cub.2010.09.003
发表时间：
2010-10-12
期刊：
Current biology : CB
影响因子：
--
作者：
Boy F;Evans CJ;Edden RA;Singh KD;Husain M;Sumner P
通讯作者：
Sumner P
影响因子：
4.7
作者：
Cosgrove, Kelly P.;Esterlis, Irina;Mason, Graeme F.;Bois, Frederic;O'Malley, Stephanie S.;Krystal, John H.
通讯作者：
Krystal, John H.
DOI：
10.1007/s00406-004-0488-z
发表时间：
2004-08-01
影响因子：
4.7
作者：
Asahi, S;Okamoto, Y;Yokota, N
通讯作者：
Yokota, N
影响因子：
10.6
作者：
Epperson, CN;O'Malley, S;Mason, GF
通讯作者：
Mason, GF
影响因子：
3.3
作者：
BEHAR, KL;OGINO, T
通讯作者：
OGINO, T