Metabolic flexibility during sleep.
Metabolic flexibility during sleep.
复制标题
DOI：
10.1038/s41598-021-97301-8
复制
发表时间：
2021-09-08
影响因子：
4.6
通讯作者：
Tokuyama K
中科院分区：
文献类型：
--
作者：
Zhang S;Tanaka Y;Ishihara A;Uchizawa A;Park I;Iwayama K;Ogata H;Yajima K;Omi N;Satoh M;Yanagisawa M;Sagayama H;Tokuyama K
被称为代谢灵活性，被氧化的底物是根据营养状态的变化而选择的。睡眠会延长禁食时间，睡眠期间氧化的底物被认为会逐渐从碳水化合物转变为脂肪，从而逐渐降低呼吸商（RQ）。与这一假设相反，改进时间分辨率的全室间接量热法显示，RQ在醒来前再次上升，非肥胖年轻人中，女性在就寝后比男性更早出现RQ最低点。在代谢不灵活的男性中，睡眠期间RQ的短暂下降被减弱，RQ的昼夜节律幅度较小。同样，10岁的年龄差异对RQ的影响在睡眠中变得显著；在老年受试者中，睡眠期间RQ的下降变得迟钝。RQ的个体间差异在睡眠中变得明显，这可能是了解代谢不灵活性早期发病机制的一个窗口。
Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
登录
查看更多内容
影响因子：
--
作者：
Iwayam K;Ogawa A;Tanaka Y;Yajima K;Park I;Ando A;Ogata H;Kayaba M;Zhang S;Tanji F;Nabekura Y;Yamamoto K;Tokuyama K
通讯作者：
Tokuyama K
影响因子：
11.1
作者：
Iwayama K;Kurihara R;Nabekura Y;Kawabuchi R;Park I;Kobayashi M;Ogata H;Kayaba M;Satoh M;Tokuyama K
通讯作者：
Tokuyama K
影响因子：
29
作者：
Goodpaster BH;Sparks LM
通讯作者：
Sparks LM
影响因子：
7.7
作者：
Kelley, DE;Mandarino, LJ
通讯作者：
Mandarino, LJ
影响因子：
6.9
作者：
Fernandez-Verdejo, Rodrigo;Castro-Sepulveda, Mauricio;Galgani, Jose E.
通讯作者：
Galgani, Jose E.