Sleeping Sickness: A Tale of Two Clocks.

Sleeping Sickness: A Tale of Two Clocks.
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DOI:
10.3389/fcimb.2020.525097
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发表时间:
2020
影响因子:
5.7
通讯作者:
Takahashi JS
Takahashi JS
中科院分区:
医学2区
文献类型:
--
作者:
Rijo-Ferreira F;Takahashi JS

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昏睡病是由已知感染野生动物、牛和人类的真核单细胞寄生虫引起的。它会导致一种致命的疾病,破坏许多有节奏的生理过程,包括激素分泌的日常节奏、温度调节和睡眠,所有这些都是在昼夜节律(24小时)控制下的。本文就昏睡病寄生虫生物学的研究进展及其对宿主健康的影响作一综述。我们还考虑了睡眠和昼夜节律失调对寄生虫可能的进化优势。
Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature regulation, and sleep, all of which are under circadian (24-h) control. In this review, we summarize research on sleeping sickness parasite biology and the impact it has on host health. We also consider the possible evolutionary advantages of sleep and circadian deregulation for the parasite.
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