Correlations between cochlear pathophysiology and behavioral measures of temporal and spatial processing in noise exposed macaques.
Correlations between cochlear pathophysiology and behavioral measures of temporal and spatial processing in noise exposed macaques.
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噪声暴露猕猴耳蜗病理生理学与时间和空间处理行为测量的相关性。
DOI：
10.1016/j.heares.2020.108156
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发表时间：
2021-03-01
期刊：
影响因子：
2.8
通讯作者：
Ramachandran R
中科院分区：
文献类型：
--
作者：
Mackey CA;McCrate J;MacDonald KS;Feller J;Liberman L;Liberman MC;Hackett TA;Ramachandran R
噪声性听力损失（NIHL）对时间、频谱和空间分辨率有显著影响。然而，关于其潜在的病理生理学仍有许多有待发现。本报告扩展了最近开发的非人灵长类动物模型NIHL，探讨其后果，在嘈杂的环境中的听力，其相关性与潜在的耳蜗病理。10只猕猴（7个听力正常，3个NIHL）被用于掩蔽音检测的研究，其中掩蔽的时间或空间属性是不同的，以评估时间和空间处理的指标。听力正常（NH）猕猴表现出较低的音调检测阈值正弦幅度调制（SAM）宽带噪声掩蔽相对于未调制掩蔽（调制掩蔽释放，MMR）。音调检测阈值在低噪声调制频率下最低，并随着调制频率的增加而增加，直到它们与未调制噪声中的阈值相匹配。NH猕猴也表现出较低的音调检测阈值空间分离的音调和噪声相对于共定位的音调和噪声（空间释放掩蔽，SRM）。噪声暴露造成永久性的阈值偏移，验证了行为和听力。在听力受损（HI）的猕猴，MMR降低音调频率以上的噪声暴露。HI猕猴也表现出退化的SRM，在所有测试的音调频率中没有观察到SRM。MMR的缺陷与测听阈值变化、外毛细胞损失和突触损失相关，而SRM的差异与测听变化或任何耳蜗病理生理学指标无关。这种解剖-行为相关性的差异表明，虽然许多行为缺陷可能源于耳蜗病理学，但只有一些可以从耳蜗损伤的频率位置预测。
Noise-induced hearing loss (NIHL) is known to have significant consequences for temporal, spectral, and spatial resolution. However, much remains to be discovered about their underlying pathophysiology. This report extends the recent development of a nonhuman primate model of NIHL to explore its consequences for hearing in noisy environments, and its correlations with the underlying cochlear pathology. Ten macaques (seven with normal-hearing, three with NIHL) were used in studies of masked tone detection in which the temporal or spatial properties of the masker were varied to assess metrics of temporal and spatial processing. Normal-hearing (NH) macaques showed lower tone detection thresholds for sinusoidally amplitude modulated (SAM) broadband noise maskers relative to unmodulated maskers (modulation masking release, MMR). Tone detection thresholds were lowest at low noise modulation frequencies, and increased as modulation frequency increased, until they matched threshold in unmodulated noise. NH macaques also showed lower tone detection thresholds for spatially separated tone and noise relative to co-localized tone and noise (spatial release from masking, SRM). Noise exposure caused permanent threshold shifts that were verified behaviorally and audiologically. In hearing-impaired (HI) macaques, MMR was reduced at tone frequencies above that of the noise exposure. HI macaques also showed degraded SRM, with no SRM observed across all tested tone frequencies. Deficits in MMR correlated with audiometric threshold changes, outer hair cell loss, and synapse loss, while the differences in SRM did not correlate with audiometric changes, or any measure of cochlear pathophysiology. This difference in anatomical-behavioral correlations suggests that while many behavioral deficits may arise from cochlear pathology, only some are predictable from the frequency place of damage in the cochlea.
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影响因子：
2.8
作者：
Bressler S;Goldberg H;Shinn-Cunningham B
通讯作者：
Shinn-Cunningham B
影响因子：
2.8
作者：
Burton JA;Mackey CA;MacDonald KS;Hackett TA;Ramachandran R
通讯作者：
Ramachandran R
影响因子：
2.4
作者：
CHERRY, EC
通讯作者：
CHERRY, EC
DOI：
10.1007/s10162-014-0467-7
发表时间：
2014-10-01
影响因子：
2.4
作者：
Bohlen, Peter;Dylla, Margit;Ramachandran, Ramnarayan
通讯作者：
Ramachandran, Ramnarayan
DOI：
10.1073/pnas.1721226115
发表时间：
2018-04-03
影响因子：
11.1
作者：
Dai L;Best V;Shinn-Cunningham BG
通讯作者：
Shinn-Cunningham BG