Associations of Food Intolerance with Irritable Bowel Syndrome, Psychological Symptoms, and Quality of Life.
Associations of Food Intolerance with Irritable Bowel Syndrome, Psychological Symptoms, and Quality of Life.
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DOI：
10.1016/j.cgh.2021.12.021
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发表时间：
2022-09
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影响因子：
--
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中科院分区：
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不同类型的食物不耐受对胃肠道症状和生活质量（QOL）的影响知之甚少。我们的目的是调查食物不耐受和不耐受类型与肠易激综合征（IBS）、健康相关QOL和心理症状的关系。我们通过在线调查对美国成年人进行了一项观察性研究。收集自我报告食物不耐受（乳糖、非乳糖食物、乳糖加食物不耐受）的参与者和无不耐受的对照者的人口统计学资料、罪魁祸首食物、症状、医学评估、罗马IV IBS标准、健康相关QOL（SF-12）和焦虑抑郁评分（HADS）。使用Kruskal-Wallis和Pearson卡方或Fisher精确检验分析组与研究终点的单变量关联。多变量比较采用逻辑回归和线性回归进行分析。共有197名患者（59名乳糖，61名非乳糖食物，77名乳糖加食物不耐受）和273名无不耐受者参加了研究。乳糖，小麦和鸡蛋是最常见的食物触发器。胀气（54.2%）、腹痛（40.2%）和腹泻（37.3%）是FI的常见症状。反应导致57.8%的人消除食物。IBS、异常焦虑评分和异常抑郁评分的发生率在乳糖加食物不耐受组中最高; SF-12评分在乳糖加食物不耐受组中最低。多变量分析显示，所有不耐受亚组比对照组更有可能患有IBS。食物不耐受与IBS、焦虑、抑郁和健康相关QOL下降相关，并经常导致食物消除。乳糖和乳糖加食物不耐受的成年人有较高的IBS发病率，心理症状增加，生活质量较差。
The impact of different types of food intolerance on gastrointestinal symptoms and quality of life (QOL) is poorly understood. We aimed to investigate associations of food intolerance and type of intolerance with irritable bowel syndrome (IBS), health-related QOL, and psychological symptoms. We conducted an observational study of US-based adults through an online survey. Demographics, culprit foods, symptoms, medical evaluation, Rome IV criteria for IBS, health-related QOL (SF-12), and anxiety and depression scores (HADS) were collected in participants with self-reported food intolerance (lactose, non-lactose food, lactose plus food intolerance), and controls with no intolerance. Univariable associations of group with study endpoints were analyzed with Kruskal-Wallis and Pearson’s chi-square or Fisher’s exact test. Multivariable comparisons were analyzed by logistic and linear regression. A total of 197 with (59 lactose, 61 non-lactose food, 77 lactose plus food intolerance) and 273 without intolerance participated. Lactose, wheat, and eggs were the most common food triggers. Gas (54.2%), abdominal pain (40.2%), and diarrhea (37.3%) were frequently reported symptoms of FI. Reactions caused 57.8% to eliminate the food. Rates of IBS, abnormal anxiety scores, and abnormal depression scores were highest in lactose plus food intolerance; SF-12 scores were lowest in lactose plus food intolerance. Multivariable analyses revealed all intolerance subgroups were more likely to have IBS than controls. Food intolerance is associated with IBS, anxiety, depression, and decreased health-related QOL and frequently leads to food elimination. Adults with lactose and lactose plus food intolerance have higher rates of IBS, increased psychological symptoms, and poorer QOL.
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3.1
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