Geographic Partitioning of Dengue Virus Transmission Risk in Florida.
Geographic Partitioning of Dengue Virus Transmission Risk in Florida.
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DOI：
10.3390/v13112232
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发表时间：
2021-11-05
期刊：
影响因子：
--
通讯作者：
Lednicky JA
中科院分区：
文献类型：
--
作者：
Stephenson CJ;Coatsworth H;Waits CM;Nazario-Maldonado NM;Mathias DK;Dinglasan RR;Lednicky JA
在节肢动物传播的病毒中，登革病毒(DENV)在全球造成最大的公共卫生负担。由于其主要蚊媒埃及伊蚊的传播范围不断扩大，DENV的传播风险也从热带地区扩大到亚热带地区。自2009年以来，美国佛罗里达州的登革热(登革热)局部暴发有所增加。然而，人们对Ae的能力知之甚少。埃及伊蚊种群跨越佛罗里达州不同地区传播DENV。为了了解DENV基因和血清型变异对FL媒介敏感性和传播潜力的影响，我们口服感染了一群Ae。埃及伊蚊(奥兰多/ORL)，低传代或实验室DENV-1至-4。低传代DENV对ORL蚊虫的感染性更强，传播潜力更大。我们用同样的DENV来检测天然的Ae。以确定空间分布是否与差异媒介能力相关。与佛罗里达州北部相比，来自佛罗里达州登革热发病率最高地区的蚊子在所有DENV血清型上的媒介能力更强。低传代DENV的媒介能力显著较高，表明传播风险受病毒/媒介组合的影响。这些数据支持有针对性的蚊子加病原体筛查方法，以更准确地估计DENV传播风险。
Dengue viruses (DENVs) cause the greatest public health burden globally among the arthropod-borne viruses. DENV transmission risk has also expanded from tropical to subtropical regions due to the increasing range of its principal mosquito vector, Aedes aegypti. Focal outbreaks of dengue fever (dengue) in the state of Florida (FL) in the USA have increased since 2009. However, little is known about the competence of Ae. aegypti populations across different regions of FL to transmit DENVs. To understand the effects of DENV genotype and serotype variations on vector susceptibility and transmission potential in FL, we orally infected a colony of Ae. aegypti (Orlando/ORL) with low passage or laboratory DENV-1 through -4. Low passage DENVs were more infectious to and had higher transmission potential by ORL mosquitoes. We used these same DENVs to examine natural Ae. aegypti populations to determine whether spatial distributions correlated with differential vector competence. Vector competence across all DENV serotypes was greater for mosquitoes from areas with the highest dengue incidence in south FL compared to north FL. Vector competence for low passage DENVs was significantly higher, revealing that transmission risk is influenced by virus/vector combinations. These data support a targeted mosquito-plus-pathogen screening approach to more accurately estimate DENV transmission risk.
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影响因子：
3.8
作者：
Guzzetta G;Trentini F;Poletti P;Baldacchino FA;Montarsi F;Capelli G;Rizzoli A;Rosà R;Merler S;Melegaro A
通讯作者：
Melegaro A
影响因子：
5.2
作者：
Angleró-Rodríguez YI;MacLeod HJ;Kang S;Carlson JS;Jupatanakul N;Dimopoulos G
通讯作者：
Dimopoulos G
影响因子：
3.8
作者：
Hladish TJ;Pearson CAB;Patricia Rojas D;Gomez-Dantes H;Halloran ME;Vazquez-Prokopec GM;Longini IM
通讯作者：
Longini IM
影响因子：
1.7
作者：
Alto, Barry W.;Smartt, Chelsea T.;Richards, Stephanie L.
通讯作者：
Richards, Stephanie L.
DOI：
10.4269/ajtmh.2012.11-0770
发表时间：
2012-10-01
影响因子：
3.3
作者：
Dick, Olivia Brathwaite;San Martin, Jose L.;Dayan, Gustavo H.
通讯作者：
Dayan, Gustavo H.