Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations.
Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations.
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DOI：
10.1016/j.diabet.2017.03.002
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发表时间：
2017-09
影响因子：
7.2
通讯作者：
Dunger DB
中科院分区：
文献类型：
--
作者：
Petry CJ;Mooslehner K;Prentice P;Hayes MG;Nodzenski M;Scholtens DM;Hughes IA;Acerini CL;Ong KK;Lowe WL Jr;Dunger DB
We hypothesised that some of the genetic risk for gestational diabetes (GDM) is due to the fetal genome affecting maternal glucose concentrations. Previously, we found associations between fetal IGF2 gene variants and maternal glucose concentrations in late pregnancy. In the present study, we tested associations between SNP alleles from 15 fetal imprinted genes and maternal glucose concentrations in late pregnancy in the Cambridge Baby Growth and Wellbeing cohorts (1160 DNA trios). Four fetal SNP alleles with the strongest univariate associations: paternally-transmitted IGF2 rs10770125 (P-value = 2 × 10–4) and INS rs2585 (P-value = 7 × 10–4), and maternally-transmitted KCNQ1(OT1) rs231841 (P-value = 1 × 10–3) and KCNQ1(OT1) rs7929804 (P-value = 4 × 10–3), were used to construct a composite fetal imprinted gene allele score which was associated with maternal glucose concentrations (P-value = 4.3 × 10–6, n = 981, r2 = 2.0%) and GDM prevalence (odds ratio per allele 1.44 (1.15, 1.80), P-value = 1 × 10–3, n = 89 cases and 899 controls). Meta-analysis of the associations including data from 1367 Hyperglycaemia and Adverse Pregnancy Outcome Study participants confirmed the paternally-transmitted fetal IGF2/INS SNP associations (rs10770125, P-value = 3.2 × 10–8, rs2585, P-value = 3.6 × 10–5) and the composite fetal imprinted gene allele score association (P-value = 1.3 × 10–8), but not the maternally-transmitted fetal KCNQ1(OT1) associations (rs231841, P-value = 0.4; rs7929804, P-value = 0.2). This study suggests that polymorphic variation in fetal imprinted genes, particularly in the IGF2/INS region, contribute a small but significant part to the risk of raised late pregnancy maternal glucose concentrations.
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影响因子：
7.7
作者：
Kwak SH;Kim SH;Cho YM;Go MJ;Cho YS;Choi SH;Moon MK;Jung HS;Shin HD;Kang HM;Cho NH;Lee IK;Kim SY;Han BG;Jang HC;Park KS
通讯作者：
Park KS
影响因子：
8.2
作者：
Cho, Y. M.;Kim, T. H.;Jang, H. C.
通讯作者：
Jang, H. C.
影响因子：
5.8
作者：
Lauenborg, Jeannet;Grarup, Niels;Hansen, Torben
通讯作者：
Hansen, Torben
影响因子：
4.5
作者：
Frost JM;Moore GE
通讯作者：
Moore GE
影响因子：
3.5
作者：
Horikoshi M;Pasquali L;Wiltshire S;Huyghe JR;Mahajan A;Asimit JL;Ferreira T;Locke AE;Robertson NR;Wang X;Sim X;Fujita H;Hara K;Young R;Zhang W;Choi S;Chen H;Kaur I;Takeuchi F;Fontanillas P;Thuillier D;Yengo L;Below JE;Tam CH;Wu Y;Abecasis G;Altshuler D;Bell GI;Blangero J;Burtt NP;Duggirala R;Florez JC;Hanis CL;Seielstad M;Atzmon G;Chan JC;Ma RC;Froguel P;Wilson JG;Bharadwaj D;Dupuis J;Meigs JB;Cho YS;Park T;Kooner JS;Chambers JC;Saleheen D;Kadowaki T;Tai ES;Mohlke KL;Cox NJ;Ferrer J;Zeggini E;Kato N;Teo YY;Boehnke M;McCarthy MI;Morris AP;T2D-GENES Consortium
通讯作者：
T2D-GENES Consortium