Age effect on subcortical structures in healthy adults.
Age effect on subcortical structures in healthy adults.
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DOI：
10.1016/j.pscychresns.2011.09.014
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发表时间：
2012-07-30
影响因子：
2.3
通讯作者：
Fein, George
中科院分区：
文献类型：
--
作者：
Goodro, Matt;Sameti, Mohammad;Patenaude, Brian;Fein, George
研究了正常对照志愿者8个皮质下结构的横断面年龄效应：侧脑室、丘脑、尾状核、壳核、苍白球、海马、杏仁核和伏隔核。对照组226例，年龄19~85岁，采用1.5T GE系统（n = 184）或3.0T Siemens系统（n = 42）扫描。使用FSL的FIRST软件（完全自动化）估计颅骨尺寸调整后的皮质下结构体积。当分析整个年龄范围时，发现所有体积均存在显着的年龄影响，然而，老年受试者（60 - 85岁）显示出年龄与心室、海马、杏仁核和伏隔核结构体积之间的相关性比中年受试者更强（35 - 60岁）。两个研究中心均对中年受试者进行了研究，尽管磁体强度和采集系统存在差异，但这些组的年龄效应相当。该协议支持本研究中使用的图像分析工具和程序的有效性。
Cross-sectional age effects in normal control volunteers were investigated in 8 subcortical structures: lateral ventricles, thalamus, caudate, putamen, pallidum, hippocampus, amygdala and nucleus accumbens. Two hundred and twenty six control subjects, ranging in age from 19 to 85 years, were scanned on a 1.5T GE system (n = 184) or a 3.0T Siemens system (n = 42). Cranium-size adjusted subcortical structure volumes were estimated using FSL’s FIRST software, which is fully automated. Significant age effects were found for all volumes when the entire age range was analyzed, however the older subjects (60–85 years of age) showed a stronger correlation between age and structural volume for the ventricles, hippocampus, amygdala and accumbens than middle-aged (35–60 years of age) subjects. Middle-aged subjects were studied at both sites, and age effects in these groups were comparable, despite differences in magnet strength and acquisition systems. This agreement lends support to the validity of the image analysis tools and procedures used in the present study.
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DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
6.6
作者：
Hantouche, EG;Angst, J;Akiskal, HS
通讯作者：
Akiskal, HS
雌激素和腔内刺激大鼠子宫泌乳素
影响因子：
3.6
作者：
Corthorn, J;Figueroa, C;Valdes, G
通讯作者：
Valdes, G
影响因子：
4.8
作者：
BUCHOLZ, KK;ROBINS, LN;SKARE, SS
通讯作者：
SKARE, SS
影响因子：
19.7
作者：
Courchesne, E;Chisum, HJ;Press, GA
通讯作者：
Press, GA