Chronic recordings reveal tactile stimuli can suppress spontaneous activity of neurons in somatosensory cortex of awake and anesthetized primates.
Chronic recordings reveal tactile stimuli can suppress spontaneous activity of neurons in somatosensory cortex of awake and anesthetized primates.
复制标题
慢性记录显示，触觉刺激可以抑制清醒和麻醉灵长类动物体感皮层神经元的自发活动。
DOI：
10.1152/jn.00634.2015
复制
发表时间：
2016
影响因子：
2.5
通讯作者：
Kaas,JonH
中科院分区：
文献类型：
--
作者：
Qi,Hui-Xin;Reed,JamieL;Franca,JoaoG;Jain,Neeraj;Kajikawa,Yoshinao;Kaas,JonH
在躯体感觉皮层中，神经元感受野（RF）内的触觉刺激通常会引起短暂的兴奋性反应，伴有或不伴有兴奋后抑制。在这里，我们描述了神经元的反应，其中刺激的手是随后的抑制正在进行的放电。使用16通道微电极阵列植入在新大陆猴和原猴的初级体感皮层的手代表，我们记录了单个单位和神经元簇的神经元反应。在我们的样本中，66%的神经元活动倾向于显示抑制时，兴奋性RF以外的皮肤区域受到刺激。在一小部分神经元中，单点压痕抑制了对手上任何测试点的反应而没有初始增加的放电。对皮肤压入的抑制反应的潜伏期（通常为12-34 ms）与兴奋反应的潜伏期相似。抑制的持续时间因神经元而异。虽然大多数观察是从麻醉动物，我们也发现了类似的神经元反应特性在一个清醒的galago。值得注意的是，抑制正在进行的神经元活动不需要条件刺激或多部位刺激。抑制作用通常在神经元最小RF之外的单部位皮肤压痕后观察到，通常在不同的手指和手掌垫上，这在这种情况下并不经常被研究。总的来说，广泛的抑制或抑制反应特性的特点，并没有初始的促进或兴奋性反应，增加了越来越多的证据表明，在初级躯体感觉皮层的神经元提供必要的处理，从整个手的感觉刺激的整合。
In somatosensory cortex, tactile stimulation within the neuronal receptive field (RF) typically evokes a transient excitatory response with or without postexcitatory inhibition. Here, we describe neuronal responses in which stimulation on the hand is followed by suppression of the ongoing discharge. With the use of 16-channel microelectrode arrays implanted in the hand representation of primary somatosensory cortex of New World monkeys and prosimian galagos, we recorded neuronal responses from single units and neuron clusters. In 66% of our sample, neuron activity tended to display suppression of firing when regions of skin outside of the excitatory RF were stimulated. In a small proportion of neurons, single-site indentations suppressed firing without initial increases in response to any of the tested sites on the hand. Latencies of suppressive responses to skin indentation (usually 12–34 ms) were similar to excitatory response latencies. The duration of inhibition varied across neurons. Although most observations were from anesthetized animals, we also found similar neuron response properties in one awake galago. Notably, suppression of ongoing neuronal activity did not require conditioning stimuli or multi-site stimulation. The suppressive effects were generally seen following single-site skin indentations outside of the neuron's minimal RF and typically on different digits and palm pads, which have not often been studied in this context. Overall, the characteristics of widespread suppressive or inhibitory response properties with and without initial facilitative or excitatory responses add to the growing evidence that neurons in primary somatosensory cortex provide essential processing for integrating sensory stimulation from across the hand.
登录
查看更多内容
影响因子：
2.5
作者：
CARLSON, M;WELT, C
通讯作者：
WELT, C
影响因子：
64.8
作者：
BOLZ, J;GILBERT, CD
通讯作者：
GILBERT, CD
警觉猴 V1 区经典感受野之外的神经元反应
影响因子：
2
作者：
Wu Li;P. Thier;C. Wehrhahn
通讯作者：
C. Wehrhahn
影响因子：
2.5
作者：
B. Mickey;J. C. Middlebrooks
通讯作者：
B. Mickey;J. C. Middlebrooks
猫头鹰猴体感皮层 3b 和 1 区的放大倍数、感受野面积和“超柱”大小。
影响因子：
2.5
作者：
M. Sur;M. Merzenich;J. Kaas
通讯作者：
J. Kaas