All-night functional magnetic resonance imaging sleep studies.
All-night functional magnetic resonance imaging sleep studies.
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DOI：
10.1016/j.jneumeth.2018.09.019
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发表时间：
2019-03-15
影响因子：
3
通讯作者：
Picchioni D
中科院分区：
文献类型：
--
作者：
Moehlman TM;de Zwart JA;Chappel-Farley MG;Liu X;McClain IB;Chang C;Mandelkow H;Özbay PS;Johnson NL;Bieber RE;Fernandez KA;King KA;Zalewski CK;Brewer CC;van Gelderen P;Duyn JH;Picchioni D
以前的功能性磁共振成像（fMRI）睡眠研究一直受到阻碍，难以获得延长睡眠量的扫描仪的睡眠不良的环境中，往往采取的操纵，如睡眠剥夺受试者在扫描前。这些操作限制了结果的普遍性。目前的研究是一个方法学验证的程序，旨在获得整夜的功能磁共振成像数据，在睡眠中的受试者与最低限度的暴露于实验诱导的睡眠剥夺。具体来说，受试者连续两晚睡在扫描仪中，第一晚作为适应之夜。第二天晚上同时采集的脑电图数据的睡眠评分结果表明，受试者（n = 12）达到了包括慢波在内的全谱睡眠阶段。（M = 52.1 min，SD = 26.5 min）和快速眼动（REM，M = 45.2分钟，SD = 27.9分钟）睡眠，并表现出平均2.1（SD = 1.1）个非REM-REM睡眠周期。结果发现，通过努力应用睡眠和神经成像科学的基本原理和方法，进行整夜的fMRI睡眠研究是可行的。然而，由于研究的两个晚上是连续进行的，因此第1个晚上的睡眠剥夺可能是第2个晚上结果的原因，因此应考虑复制当前研究并设置洗脱期。据设想，其他实验室可以采用该方案的核心特征，以获得类似的结果。
Previous functional magnetic resonance imaging (fMRI) sleep studies have been hampered by the difficulty of obtaining extended amounts of sleep in the sleep-adverse environment of the scanner and often have resorted to manipulations such as sleep depriving subjects before scanning. These manipulations limit the generalizability of the results. The current study is a methodological validation of procedures aimed at obtaining all-night fMRI data in sleeping subjects with minimal exposure to experimentally induced sleep deprivation. Specifically, subjects slept in the scanner on two consecutive nights, allowing the first night to serve as an adaptation night. Sleep scoring results from simultaneously acquired electroencephalography data on Night 2 indicate that subjects (n = 12) reached the full spectrum of sleep stages including slow-wave (M = 52.1 min, SD = 26.5 min) and rapid eye movement (REM, M = 45.2 min, SD = 27.9 min) sleep and exhibited a mean of 2.1 (SD = 1.1) nonREM-REM sleep cycles. It was found that by diligently applying fundamental principles and methodologies of sleep and neuroimaging science, performing all-night fMRI sleep studies is feasible. However, because the two nights of the study were performed consecutively, some sleep deprivation from Night 1 as a cause of the Night 2 results is likely, so consideration should be given to replicating the current study with a washout period. It is envisioned that other laboratories can adopt the core features of this protocol to obtain similar results.
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影响因子：
2.6
作者：
Chen, Michael C.;Chang, Catie;Glover, Gary H.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
DOI：
10.1016/j.nicl.2017.07.008
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bagshaw AP;Hale JR;Campos BM;Rollings DT;Wilson RS;Alvim MKM;Coan AC;Cendes F
通讯作者：
Cendes F
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.
影响因子：
5.3
作者：
Andrade, Katia C.;Spoormaker, Victor I.;Czisch, Michael
通讯作者：
Czisch, Michael
影响因子：
2.4
作者：
Chambers, J;Akeroyd, MA;Palmer, AR
通讯作者：
Palmer, AR