Sleep onset uncovers thalamic abnormalities in patients with idiopathic generalised epilepsy.
Sleep onset uncovers thalamic abnormalities in patients with idiopathic generalised epilepsy.
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DOI：
10.1016/j.nicl.2017.07.008
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Cendes F
中科院分区：
文献类型：
--
作者：
Bagshaw AP;Hale JR;Campos BM;Rollings DT;Wilson RS;Alvim MKM;Coan AC;Cendes F
丘脑对于睡眠调节和特发性全面性癫痫（IGE）的病理生理学至关重要，并且可能是两者之间联系的潜在基础。我们利用脑电图 - 功能性磁共振成像（EEG - fMRI）并特别强调丘脑的作用和功能连接（FC）对此进行了研究。我们定义了三种丘脑功能连接类型：丘脑 - 皮质、丘脑半球间和丘脑半球内。患者和对照组在这三项指标上均存在差异，并且在清醒和睡眠期间都有差异，这表明丘脑功能连接存在疾病依赖性和状态依赖性的改变。在清醒时，患者和对照组在躯体感觉区域的丘脑半球间功能连接存在差异，在睡眠时则在枕叶区域存在差异。在睡眠开始后，患者的丘脑半球内功能连接显著高于对照组，并且在几个丘脑区域（总是涉及躯体运动和枕叶区域）观察到功能连接的疾病依赖性改变。由于丘脑亚区之间的相互作用是间接的，并由抑制性丘脑网状核（TRN）介导，结果表明IGE患者的丘脑网状核功能异常，其区域分布可能暗示与产生α节律的丘脑 - 皮质网络存在联系。丘脑内功能连接可能是一种在IGE患者之外更广泛适用的标志物。
睡眠开始对全面性癫痫患者丘脑功能连接的改变与对照组不同。
差异具有区域特异性。
与躯体运动/枕叶皮质相连的区域始终受到影响。
丘脑内功能连接可能是丘脑网状核功能的一个替代标志物。
The thalamus is crucial for sleep regulation and the pathophysiology of idiopathic generalised epilepsy (IGE), and may serve as the underlying basis for the links between the two. We investigated this using EEG-fMRI and a specific emphasis on the role and functional connectivity (FC) of the thalamus. We defined three types of thalamic FC: thalamocortical, inter-hemispheric thalamic, and intra-hemispheric thalamic. Patients and controls differed in all three measures, and during wakefulness and sleep, indicating disorder-dependent and state-dependent modification of thalamic FC. Inter-hemispheric thalamic FC differed between patients and controls in somatosensory regions during wakefulness, and occipital regions during sleep. Intra-hemispheric thalamic FC was significantly higher in patients than controls following sleep onset, and disorder-dependent alterations to FC were seen in several thalamic regions always involving somatomotor and occipital regions. As interactions between thalamic sub-regions are indirect and mediated by the inhibitory thalamic reticular nucleus (TRN), the results suggest abnormal TRN function in patients with IGE, with a regional distribution which could suggest a link with the thalamocortical networks involved in the generation of alpha rhythms. Intra-thalamic FC could be a more widely applicable marker beyond patients with IGE. Sleep onset modifies thalamic FC in generalised epilepsy differently to controls. Differences are regionally specific. Regions connected to somatomotor/occipital cortices are consistently affected. Intra-thalamic FC may be a surrogate marker of thalamic reticular nucleus function.
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影响因子：
5.7
作者：
Hale, Joanne R.;White, Thomas P.;Bagshaw, Andrew P.
通讯作者：
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影响因子：
6.6
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2.2
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64.5
作者：
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影响因子：
16.2
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通讯作者：
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