The adverse cardiac effects of Di(2-ethylhexyl)phthalate and Bisphenol A.
The adverse cardiac effects of Di(2-ethylhexyl)phthalate and Bisphenol A.
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DOI：
10.1007/s12012-014-9258-y
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发表时间：
2014-12
影响因子：
3.2
通讯作者：
Posnack, Nikki Gillum
中科院分区：
文献类型：
--
作者：
Posnack, Nikki Gillum
关键词：
The ubiquitous nature of plastics has raised concerns pertaining to continuous exposure to plastic polymers and human health risks. Of particular concern is the use of endocrine-disrupting chemicals (EDCs) in plastic production, including Di(2-ethylhexyl) phthalate (DEHP) and Bisphenol A (BPA). Widespread and continuous exposure to DEHP and BPA occurs through dietary intake, inhalation, dermal and intravenous exposure via consumer products and medical devices. This article reviews the literature examining the relationship between DEHP and BPA exposure and cardiac toxicity. In vitro and in vivo experimental reports are outlined, as well as epidemiological studies which examine the association between these chemicals and cardiovascular outcomes. Gaps in our current knowledge are also discussed, along with future investigative endeavors that may help resolve whether DEHP and/or BPA exposure has a negative impact on cardiovascular physiology.
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