Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study.
Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study.
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DOI：
10.1002/mds.25144
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发表时间：
2012-09-15
影响因子：
8.6
通讯作者：
White, Lon R.
中科院分区：
文献类型：
--
作者：
Ross, G. Webster;Duda, John E.;Abbott, Robert D.;Pellizzari, Edo;Petrovitch, Helen;Miller, Diane B.;O'Callaghan, James P.;Tanner, Caroline M.;Noorigian, Joseph V.;Masaki, Kamal;Launer, Lenore;White, Lon R.
虽然有机氯在帕金森病（PD）大脑中的报告频率高于对照组，但与脑路易病理学的关联尚不清楚。檀香山-亚洲老龄化研究（哈斯）的参与者，暴露于有机氯从各种来源在中年，代表一个人口非常适合确定脑有机氯与路易病理学的关系，从纵向哈斯死亡。研究设计包括测量哈斯死者枕叶冷冻样本中21种有机氯水平。在225个脑中进行的α-突触核蛋白免疫染色用于识别路易体和路易神经突。由于路易氏病与发现存在于至少一个大脑中的17种有机氯化合物之间可能出现虚假关联，初步评估确定七氯环氧化物异构体B、甲氧滴滴涕和苯六氯B最为重要。在具有3种化合物中的任何2种的脑中，Lewy病理学的患病率为75%（6/8），在具有1种化合物的脑中为48.8%（79/162），在两种化合物均不具有的脑中为32.7%（18/55）（趋势检验P=0.007）。虽然在排除PD和路易体痴呆病例后，以及在对死亡年龄、体重指数、吸烟包年数和咖啡摄入量进行调整后，结果仍然存在（p=0.013），但在校正多重测试后，结果并不显著。虽然与早期的帐户有机氯和临床PD之间的关联一致，与路易病理学的关联值得进一步研究。
Although organochlorines have been reported more frequently in Parkinson’s disease (PD) brains than controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during mid-life, represent a population well suited to determine the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. Study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found to be present in at least one brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. Prevalence of Lewy pathology was 75% (6/8) among brains with any 2 of the 3 compounds, 48.8% (79/162) among those with 1, and 32.7% (18/55) for those with neither (P=0.007 test for trend). While findings persisted after removing cases with PD and dementia with Lewy bodies, and when adjustments were made for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (p=0.013), results were insignificant when correcting for multiple testing. While consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.
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影响因子：
1.9
作者：
LANE, PW;NELDER, JA
通讯作者：
NELDER, JA
影响因子：
3.4
作者：
Richardson, Jason R.;Roy, Ananya;German, Dwight C.
通讯作者：
German, Dwight C.
影响因子：
3.8
作者：
Rusiecki, JA;Matthews, A;Barisi, D
通讯作者：
Barisi, D
影响因子：
--
作者：
Richardson, Jason R.;Shalat, Stuart L.;Buckley, Brian;Winnik, Bozena;O'Suilleabhain, Padraig;Diaz-Arrastia, Ramon;Reisch, Joan;German, Dwight C.
通讯作者：
German, Dwight C.
影响因子：
9.9
作者：
Petrovitch, H;White, LR;Markesbery, WR
通讯作者：
Markesbery, WR