Preterm infant linear growth and adiposity gain: trade-offs for later weight status and intelligence quotient.
Preterm infant linear growth and adiposity gain: trade-offs for later weight status and intelligence quotient.
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DOI：
10.1016/j.jpeds.2013.06.032
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
McCormick MC
中科院分区：
文献类型：
--
作者：
Belfort MB;Gillman MW;Buka SL;Casey PH;McCormick MC
在早产儿中，检查学龄期和青年期认知结果与超重/肥胖之间的权衡，与婴儿期体重增加和线性生长有关。我们研究了945名参与婴儿健康与发育计划的参与者，这是一项针对早产（≤37周）、低出生体重（≤2500克）婴儿从出生到18岁的8中心研究。在logistic回归中调整了母亲和儿童因素，我们估计了超重/肥胖的几率（8岁时BMI ≥第85百分位数或18岁时≥25 kg/m2），并在单独的模型中，根据婴儿身长和BMI从足月到4个月、4-12个月和12-18个月的z评分变化，估计了低智商（<85）的几率。从足月到4个月更快的线性增长与8岁时智商<85的几率较低相关（OR 0.82，95% CI 0.70，0.96），但超重/肥胖的几率较高（OR 1.27，95% CI 1.05，1.53）。在所有3个婴儿时间间隔内，BMI增加更快也与超重/肥胖的几率更高相关，并且从4-12个月开始，8岁时IQ <85的几率更低。18岁时的结果相似。在20世纪80年代出生的早产儿、低出生体重儿中，足月后不久较快的线性生长与较好的认知能力有关，但也与8岁和18岁时超重/肥胖的风险较高有关。在整个18个月后，BMI的增加与以后超重/肥胖的风险有关，但对智商有益的证据较少。
Among preterm infants, to examine tradeoffs between cognitive outcome and overweight/obesity at school age and in young adulthood in relation to infancy weight gain and linear growth. We studied 945 participants in the Infant Health and Development Program, an 8-center study of preterm (≤37 weeks), low birth weight (≤2500 grams) infants from birth to 18 years. Adjusting for maternal and child factors in logistic regression, we estimated the odds of overweight/obesity (BMI ≥85th percentile at age 8 or ≥25 kg/m2 at age 18) and in separate models, low IQ (<85) per z-score change in infant length and BMI from term to 4 months, 4-12 months, and 12-18 months. More rapid linear growth from term to 4 months was associated with lower odds of IQ<85 at age 8 (OR 0.82, 95% CI 0.70, 0.96), but a higher odds of overweight/obesity (OR 1.27, 95% CI 1.05, 1.53). More rapid BMI gain in all 3 infant time intervals was also associated with a higher odds of overweight/obesity, and from 4-12 months with a lower odds of IQ <85 at age 8. Results at age 18 were similar. In preterm, low birth weight infants born in the 1980’s, faster linear growth soon after term was associated with better cognition but also with a higher risk of overweight/obesity at 8 and 18 years of age. BMI gain over the entire 18 months after term was associated with later risk of overweight/obesity, with less evidence for a benefit to IQ.
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影响因子：
8
作者：
Belfort MB;Rifas-Shiman SL;Rich-Edwards JW;Kleinman KP;Oken E;Gillman MW
通讯作者：
Gillman MW
影响因子：
9.8
作者：
Bukowski, R;Gahn, D;Saade, G
通讯作者：
Saade, G
影响因子：
2.5
作者：
Kan, Erick;Roberts, Gehan;Doyle, Lex W.
通讯作者：
Doyle, Lex W.
影响因子：
5
作者：
Lu, Frank Leigh;Hsieh, Chia-Jung;Lin, Ruey-Shiung
通讯作者：
Lin, Ruey-Shiung
影响因子：
5.1
作者：
MCCORMICK, MC;MCCARTON, C;BROOKSGUNN, J
通讯作者：
BROOKSGUNN, J