Immunology of the varicella-zoster virus glycoproteins.
Immunology of the varicella-zoster virus glycoproteins.
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水痘带状疱疹病毒糖蛋白的免疫学。
DOI：
10.1093/infdis/157.5.877
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Litwin,V
中科院分区：
文献类型：
--
作者：
Grose,C;Litwin,V
在杂交瘤技术出现之前，对病毒感染，特别是水痘带状疱疹病毒（VZV）的免疫应答尚未得到广泛研究。在本期杂志中，Dubey et al. [1]提供了关于VZV感染和VZV免疫后体液免疫应答的新信息。本观点的目的是简要回顾旧的数据，然后集中在最近的文章中描述VZV感染的免疫反应。病毒糖蛋白及其在VZV感染的免疫应答中的作用将被强调，原因有二：（1）它们一直是几项研究的焦点，（2）它们含有具有重要生物活性（如中和）的免疫优势表位。许多有争议的文章都在《华尔街日报》上发表。对病毒感染的体液或B细胞应答包括诱导免疫球蛋白IgM和IgG针对特异性抗原。从抗体结合的立体化学研究，现在很明显，许多参与抗体与抗原决定簇（或表位）相互作用的因素依赖于高水平的蛋白质结构。两种类型的行列式被认为存在：连续和不连续[2]。连续决定簇，也称为线性表位，由短的连续氨基酸段组成。另一方面，不连续决定簇由来自分子不连续部分的氨基酸残基组成，这些氨基酸残基通过蛋白质在其天然结构中的折叠而聚集在一起[2，3]。决定簇的微环境可以影响抗原性的程度。最具抗原性的表位以三维超组装体为特征，作者的研究得到了国家过敏和传染病研究所的AI-22795资助和美国癌症协会的MV-359资助。VL是美国农业部生物技术培训计划84-格拉德-9-0024的研究生奖学金获得者。请向查尔斯·格罗斯博士提出重印请求，
The immune responses to viral infection, in general, and to varicella-zoster virus (VZV), in particular, had not been widely studied until the advent of hybridoma technology. In this issue of the Journal, Dubey et al.[1] present new information about the humoral immune response following VZV infection and VZV immunization. The goal of this Perspective is to briefly review older data and then concentrate on recent articles that characterize the immune response to VZV infection. The viral glycoproteins and their role in the immune response to VZV infection will be emphasized for two reasons:(1) they have been the focus of several studies, and (2) they harbor immuno-dominant epitopes with important biologic activity, eg, neutralization. Appropriately, many of the rele-vant articles have been published in the Journal. The humoral or B cell responses to viral infection include the induction of immunoglobulins IgM and IgG to specific antigens. From stereochemical studies of antibody binding, it is now apparent that many of the factors involved in the interaction of antibody with the antigenic determinant (or epitope) are dependent on high-level protein structure. Two types of determinants are thought to exist: continuous and discontinuous [2]. Continuous determinants, also called linear epitopes, consist of short sequential stretches of amino acids. On the other hand, discon-tinuous determinants are composed of amino acid residues from noncontiguous parts of the molecule that are brought together by folding of the protein in its native structure [2, 3]. The microenvironment of the determinant can influence the degree of antigenicity. Epitopes that are most antigenic are characterized by three-dimensional superassemblies withResearch by the authors is supported by grant AI-22795 from the National Institute of Allergy and Infectious Diseases and by grant MV-359 from the American Cancer Society. VL is the recipient of a graduate fellowship from the US Department of Agriculture biotechnology training program 84-GRAD-9-0024. Please address requests for reprints to Dr. Charles Grose,
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用水痘带状疱疹抗原补充固定研究。
影响因子：
4.4
作者：
E. Gold;G. Godek
通讯作者：
G. Godek
水痘带状疱疹病毒三大糖蛋白的抗体：寻找相关的宿主免疫反应。
影响因子：
6.4
作者：
P. Brunell;V. Novelli;P. Keller;R. Ellis
通讯作者：
R. Ellis
水痘带状疱疹病毒对天然病毒糖蛋白 gp118（VZV 糖蛋白 gpIII）的中和表位。
影响因子：
3.7
作者：
Montalvo,EA;Grose,C
通讯作者：
Grose,C
影响因子：
158.5
作者：
A. Gershon;S. Steinberg;P. Brunell
通讯作者：
P. Brunell
病毒特异性免疫球蛋白M对妊娠中期先天性水痘综合征的产前诊断。
DOI：
10.1016/s0022-3476(87)80128-2
发表时间：
1987
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Cuthbertson,G;Weiner,CP;Giller,RH;Grose,C
通讯作者：
Grose,C