Attention enhancing effects of methylphenidate are age-dependent.
Attention enhancing effects of methylphenidate are age-dependent.
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DOI：
10.1016/j.exger.2014.11.006
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发表时间：
2015-01
影响因子：
3.9
通讯作者：
Waterhouse, Barry D.
中科院分区：
文献类型：
--
作者：
Bhattacharya, Shevon E.;Shumsky, Jed S.;Waterhouse, Barry D.
精神兴奋剂哌醋甲酯（MPH，利他林®）用于治疗各种认知障碍。MPH在包括老年人在内的健康人群中也很受欢迎，因为它具有集中注意力和提高注意力的能力，但这些效果在老年人和成人受试者之间没有可比性。因此，我们测试了MPH是否会提高成年和老年大鼠的持续注意力表现。此外，我们还测试了视觉分心对任务表现的影响，以及MPH减轻分心影响的能力。给成年（6-12月龄）和成年（18-22月龄）雄性sd大鼠口服MPH，测试其认知和运动能力。结果表明，MPH可以提高成人的任务绩效；年老的动物没有任何改善。这些结果表明，使用MPH来增强老年人的认知能力可能是无效的。
The psychostimulant methylphenidate (MPH, Ritalin®) is used to treat a variety of cognitive disorders. MPH is also popular among healthy individuals, including the elderly, for its ability to focus attention and improve concentration, but these effects have not been shown to be comparable between aged and adult subjects. Thus, we tested whether MPH would improve performance in sustained attention in both adult and aged rats. In addition, we tested the impact of visual distraction on performance in this task and the ability of MPH to mitigate the effects of distraction. Adult (6–12 months) and aged (18–22 months) male Sprague-Dawley rats were given oral MPH, and their cognitive and motor abilities were tested. Results suggest that while MPH improves task performance in adults; there is no improvement in the aged animals. These outcomes suggest that use of MPH for cognitive enhancement in elderly individuals may be ineffective.
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影响因子：
2.5
作者：
GLOCK, D;GAURON, EF;ROWLEY, VN
通讯作者：
ROWLEY, VN
影响因子：
3
作者：
Donfrancesco, Renato;Parisi, Pasquale;Cortese, Samuele
通讯作者：
Cortese, Samuele
影响因子：
4.2
作者：
Grudzien, Aneta;Shaw, Pamela;Mesulam, M. Marsel
通讯作者：
Mesulam, M. Marsel
影响因子：
10.6
作者：
Devilbiss, David M.;Berridge, Craig W.
通讯作者：
Berridge, Craig W.
影响因子：
4.2
作者：
Ishida, Y;Shirokawa, T;Isobe, K
通讯作者：
Isobe, K