A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children.
A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children.
复制标题
DOI：
10.1016/j.brainres.2010.08.049
复制
发表时间：
2010-10-28
期刊：
影响因子：
2.9
通讯作者：
Kramer AF
中科院分区：
文献类型：
--
作者：
Chaddock L;Erickson KI;Prakash RS;Kim JS;Voss MW;Vanpatter M;Pontifex MB;Raine LB;Konkel A;Hillman CH;Cohen NJ;Kramer AF
由于儿童变得超重、不健康且体质不佳，了解儿童时期积极生活方式在神经认知方面的益处对公共健康和教育具有重要意义。动物研究表明，有氧运动与海马体中细胞增殖和存活的增加以及海马体依赖性学习和记忆的增强有关。近期的证据将这种关系延伸到了老年人，表明老年人较高的有氧适能水平与海马体体积增大和更好的记忆表现相关。本研究旨在进一步将适能、海马体体积和记忆之间的联系扩展到一个青春期前儿童的样本中。为此，采用磁共振成像技术来研究体能较高和较低的9岁和10岁儿童在海马体体积上是否存在差异，以及这些差异是否与项目记忆和关系记忆任务的表现有关。关系记忆主要由海马体支持，而非项目记忆。与预测一致，体能较高的儿童与体能较低的儿童相比，双侧海马体体积更大，关系记忆任务表现更优。海马体体积也与关系记忆任务的表现呈正相关，而与项目记忆任务无关。此外，发现双侧海马体体积介导了体能水平（最大摄氧量）和关系记忆之间的关系。有氧适能、伏隔核体积和记忆之间没有相关关系的报道，这加强了体能对海马体特定影响的假设。这些发现首次表明有氧适能可能与青春期前人类大脑的结构和功能有关。
Because children are becoming overweight, unhealthy, and unfit, understanding the neurocognitive benefits of an active lifestyle in childhood has important public health and educational implications. Animal research has indicated that aerobic exercise is related to increased cell proliferation and survival in the hippocampus as well as enhanced hippocampal-dependent learning and memory. Recent evidence extends this relationship to elderly humans by suggesting that high aerobic fitness levels in older adults are associated with increased hippocampal volume and superior memory performance. The present study aimed to further extend the link between fitness, hippocampal volume, and memory to a sample of preadolescent children. To this end, magnetic resonance imaging was employed to investigate whether higher- and lower-fit 9- and 10-year-old children showed differences in hippocampal volume and if the differences were related to performance on an item and relational memory task. Relational but not item memory is primarily supported by the hippocampus. Consistent with predictions, higher-fit children showed greater bilateral hippocampal volumes and superior relational memory task performance compared to lower-fit children. Hippocampal volume was also positively associated with performance on the relational but not the item memory task. Furthermore, bilateral hippocampal volume was found to mediate the relationship between fitness level (VO2 max) and relational memory. No relationship between aerobic fitness, nucleus accumbens volume, and memory was reported, which strengthens the hypothesized specific effect of fitness on the hippocampus. The findings are the first to indicate that aerobic fitness may relate to the structure and function of the preadolescent human brain.
登录
查看更多内容
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1097/00004583-200109000-00009
发表时间：
2001-09-01
影响因子：
13.3
作者：
Durston, S;Pol, HEH;van Engeland, H
通讯作者：
van Engeland, H
影响因子：
158.5
作者：
Baker, Jennifer L.;Olsen, Lina W.;Sorensen, Thorkild I. A.
通讯作者：
Sorensen, Thorkild I. A.
影响因子：
6.6
作者：
Casey, B. J.;Getz, Sarah;Galvan, Adriana
通讯作者：
Galvan, Adriana
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL