Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study.
Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study.
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DOI：
10.1016/j.jad.2011.01.020
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发表时间：
2011-07
影响因子：
6.6
通讯作者：
Resnick, Susan
中科院分区：
文献类型：
--
作者：
Goveas, Joseph S.;Espeland, Mark A.;Hogan, Patricia;Dotson, Vonetta;Tarima, Sergey;Coker, Laura H.;Ockene, Judith;Brunner, Robert;Woods, Nancy F.;Wassertheil-Smoller, Sylvia;Kotchen, Jane M.;Resnick, Susan
关键词：
晚年抑郁症状（DS）增加了老年人发生轻度认知障碍和可能痴呆的风险。我们的目的是检查DS升高和区域脑容量（包括额叶亚区、海马和杏仁核）之间的关系，并确定DS升高是否与绝经后妇女亚临床脑血管疾病增加相关。在1372名女性中，在结构脑MRI之前平均8年评估DS。使用8项Burnam回归算法定义DS，临界点为0.009。校正潜在混杂因素后，比较了患有和不患有DS的女性的总脑、额叶亚区、海马和杏仁核体积以及基底节和基底节外的脑白色和灰质的总缺血性病变体积的平均差异。抑郁的女性有较低的基线整体认知，更可能有激素治疗史。完全校正后，基线DS与较小的上级和中间额回体积相关。抑郁症和非抑郁症女性的海马和杏仁核体积以及缺血性病变体积相似。抑郁症没有评估的基础上半结构化的采访，我们无法确定DS和额叶体积差异之间的时间关系，由于只有一个MRI扫描的可用性。DS升高与某些额叶子区域的体积降低相关，但与内侧颞叶结构无关。我们的研究结果支持额叶结构在女性晚年DS中的作用。
Late-life depressive symptoms (DS) increase the risk of incident mild cognitive impairment and probable dementia in the elderly. Our objectives were to examine the relationship between elevated DS and regional brain volumes including frontal lobe subregions, hippocampus and amygdala, and to determine whether elevated DS were associated with increased subclinical cerebrovascular disease in postmenopausal women. DS were assessed an average of 8 years prior to structural brain MRI in 1372 women. The 8-item Burnam regression algorithm was used to define DS with a cut-point of 0.009. Adjusting for potential confounders, mean differences in total brain, frontal lobe subregions, hippocampus and amygdala volumes and total ischemic lesion volumes in the basal ganglia and the cerebral white and gray matter outside the basal ganglia were compared between women with and without DS. Depressed women had lower baseline global cognition and were more likely to have prior hormone therapy history. After full adjustment, DS at baseline were associated with smaller superior and middle frontal gyral volumes. Hippocampal and amygdala volumes, and ischemic lesion volumes were similar in depressed and non-depressed women. Depression was not assessed based on semi-structured interview, and we were unable to determine the temporal relationships between DS and frontal lobe volume differences due to the availability of only one MRI scan. Elevated DS were associated with lower volumes in certain frontal lobe subregions but not in the medial temporal lobe structures. Our findings support the role of frontal lobe structures in late-life DS among women.
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影响因子：
4.8
作者：
Jaramillo, Sarah A.;Felton, Deborah;Espeland, Mark A.
通讯作者：
Espeland, Mark A.
影响因子：
2.1
作者：
Butters, Meryl A.;Klunk, William E.;Meltzer, Carolyn C.
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影响因子：
6.3
作者：
Goveas JS;Espeland MA;Woods NF;Wassertheil-Smoller S;Kotchen JM
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Kotchen JM
影响因子：
7.2
作者：
Dotson, Vonetta M.;Resnick, Susan M.;Zonderman, Alan B.
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Zonderman, Alan B.
影响因子：
9.9
作者：
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通讯作者：
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