Central serous chorioretinopathy in active endogenous Cushing's syndrome.
Central serous chorioretinopathy in active endogenous Cushing's syndrome.
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DOI：
10.1038/s41598-021-82536-2
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发表时间：
2021-02-02
影响因子：
4.6
通讯作者：
van Dijk EHC
中科院分区：
文献类型：
--
作者：
Brinks J;van Haalen FM;van Rijssen TJ;Biermasz NR;Meijer OC;Pereira AM;Boon CJF;van Dijk EHC
多个病例系列提供的证据表明，活动性库欣综合征（CS）患者中心性浆液性脉络膜视网膜病变（CSC）的发生率相对较高。在这项前瞻性队列研究中，我们详细描述了连续患有活动性内源性 CS（无论是新发的还是复发性活动性内源性 CS）的患者的眼科状态。所有患者均接受了完整的眼科检查，包括多模态成像，这是在高皮质醇血症状态下活动性 CS 诊断成立后不久进行的。包括 11 名患有活动性皮质醇增多症的 CS 患者（4 名男性，7 名女性）。在 3 名患者中发现了类似（亚临床）CSC 的异常现象。光学相干断层扫描 (OCT) 显示 1 名患者黄斑视网膜下液，该患者被诊断为活动性 CSC，并成功接受了半剂量光动力疗法。另外两名患者表现出 CSC 样异常：一名患者 OCT 显示单侧假卵黄样病变，荧光素血管造影显示高荧光变化，另一名患者荧光素血管造影显示单侧渗漏。增强深度成像 OCT 的平均中心凹下脉络膜厚度为 270±40 μm（范围：178 – 357 μm）。在活动性 CS 患者中，类似于（亚临床）CSC 的视网膜异常可能比之前认为的更为常见，甚至在没有视力不适的患者中也可能存在。对于出现视觉症状的 CS 患者，临床医生应降低眼科评估的门槛，因为可能存在预防视力丧失的治疗机会。
Multiple case series have provided evidence for a relatively high incidence of central serous chorioretinopathy (CSC) in patients with active Cushing’s syndrome (CS). We describe the ophthalmological status in detail of consecutive patients with active endogenous CS (either de novo or recurrent active endogenous CS) in this prospective cohort study. All patients underwent complete ophthalmological examination, including multimodal imaging, which was performed shortly after establishing the diagnosis of active CS in hypercortisolemic state. Eleven CS patients (4 men, 7 women) with active hypercortisolism were included. Abnormalities reminiscent of (subclinical) CSC were found in 3 patients. Optical coherence tomography (OCT) revealed macular subretinal fluid in 1 patient, who was diagnosed as having active CSC and was successfully treated with half-dose photodynamic therapy. Two other patients showed CSC-like abnormalities: an unilateral pseudovitelliform lesion on OCT and hyperfluorescent changes on fluorescein angiography in one patient, and unilateral leakage on fluorescein angiography in the other patient. Mean subfoveal choroidal thickness on enhanced depth imaging OCT was 270 ± 40 μm (range, 178 – 357 μm). Retinal abnormalities resembling (subclinical) CSC may be more common than previously thought in patients with active CS, and may exist even in patients without visual complaints. Clinicians should have a low threshold for ophthalmological evaluation in case of a CS patient with visual symptoms since there may be therapeutic opportunities to prevent vision loss.
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DOI：
10.1097/iae.0000000000001198
发表时间：
2017-03-01
影响因子：
3.3
作者：
Karaca, Cagatay;Karaca, Zuleyha;Mirza, Galip Ertugrul
通讯作者：
Mirza, Galip Ertugrul
影响因子：
5.2
作者：
Abalem MF;Machado MC;Santos HN;Garcia R;Helal J Jr;Carricondo PC;Pimentel SL;Monteiro ML;Qian CX;Bronstein MD;Fragoso MC
通讯作者：
Fragoso MC
影响因子：
13.7
作者：
Carvalho-Recchia, CA;Yannuzzi, LA;Iida, T
通讯作者：
Iida, T
DOI：
10.1007/s00417-017-3823-6
发表时间：
2017-12-01
影响因子：
2.7
作者：
van Dijk, Elon H. C.;Soonawala, Darius;Boon, Camiel J. F.
通讯作者：
Boon, Camiel J. F.
影响因子：
5.8
作者：
Lindsay, JR;Nansel, T;Nieman, LK
通讯作者：
Nieman, LK