The pace of evolution across fitness valleys.
The pace of evolution across fitness valleys.
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DOI:
10.1016/j.jtbi.2009.04.011
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发表时间:
2009-08-07
影响因子:
2
通讯作者:
Traulsen, Arne
中科院分区:
文献类型:
--
作者:
Gokhale, Chaitanya S.;Iwasa, Yoh;Nowak, Martin A.;Traulsen, Arne
How fast does a population evolve from one fitness peak to another? We study the dynamics of evolving, asexually reproducing populations in which a certain number of mutations jointly confer a fitness advantage. We consider the time until a population has evolved from one fitness peak to another one with a higher fitness. The order of mutations can either be fixed or random. If the order of mutations is fixed, then the population follows a metaphorical ridge, a single path. If the order of mutations is arbitrary, then there are many ways to evolve to the higher fitness state. We address the time required for fixation in such scenarios and study how it is affected by the order of mutations, the population size, the fitness values and the mutation rate.
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影响因子:
3.3
作者:
Jain, Kavita;Krug, Joachim
通讯作者:
Krug, Joachim
DOI:
10.1073/pnas.37.3.146
发表时间:
1951-01-01
影响因子:
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作者:
ATWOOD, KC;SCHNEIDER, LK;RYAN, FJ
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作者:
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Muller, HJ
DOI:
10.1073/pnas.0712345105
发表时间:
2008-03-18
影响因子:
11.1
作者:
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通讯作者:
Markowitz, Sanford D.
影响因子:
4.3
作者:
Beerenwinkel, Niko;Antal, Tibor;Dingli, David;Traulsen, Arne;Kinzler, Kenneth W.;Velculescu, Victor E.;Vogelstein, Bert;Nowak, Martin A.
通讯作者:
Nowak, Martin A.