The pace of evolution across fitness valleys.

The pace of evolution across fitness valleys.
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DOI:
10.1016/j.jtbi.2009.04.011
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发表时间:
2009-08-07
影响因子:
2
通讯作者:
Traulsen, Arne
Traulsen, Arne
中科院分区:
生物学4区
文献类型:
--
作者:
Gokhale, Chaitanya S.;Iwasa, Yoh;Nowak, Martin A.;Traulsen, Arne

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一个群体从一个健康高峰到另一个健康高峰的进化速度有多快?我们研究进化的、无性繁殖的种群的动态,在这些种群中,一定数量的突变共同赋予适应度优势。我们考虑种群从一个健康高峰进化到另一个具有更高健康水平的高峰的时间。突变的顺序可以是固定的,也可以是随机的。如果突变的顺序是固定的,那么种群就会沿着一条隐喻的山脊,一条单一的路径前进。如果突变的顺序是任意的,那么有很多方法可以进化到更高的适应度状态。我们解决了这种情况下固定所需的时间,并研究了突变顺序、种群大小、适应值和突变率对固定时间的影响。
How fast does a population evolve from one fitness peak to another? We study the dynamics of evolving, asexually reproducing populations in which a certain number of mutations jointly confer a fitness advantage. We consider the time until a population has evolved from one fitness peak to another one with a higher fitness. The order of mutations can either be fixed or random. If the order of mutations is fixed, then the population follows a metaphorical ridge, a single path. If the order of mutations is arbitrary, then there are many ways to evolve to the higher fitness state. We address the time required for fixation in such scenarios and study how it is affected by the order of mutations, the population size, the fitness values and the mutation rate.
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