Avian influenza: a new pandemic threat?
Avian influenza: a new pandemic threat?
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禽流感：一种新的大流行威胁？
DOI：
10.4065/79.4.523
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发表时间：
2004-04
影响因子：
8.9
通讯作者：
Baddour LM
中科院分区：
文献类型：
--
作者：
Trampuz A;Prabhu RM;Smith TF;Baddour LM
2003年12月，在8个亚洲国家的家禽中爆发了最大规模的高致病性禽流感H5N1。越南和泰国报告了有限数量的人类H5N1感染，死亡率接近70%。死亡发生在健康的年轻人身上，这让人想起1918年西班牙流感大流行。主要临床表现为发热、肺炎、淋巴细胞减少和腹泻。值得注意的是，没有咽喉痛、结膜炎和鼻炎。H5N1病毒株对金刚烷胺和金刚乙胺有抗药性，但对可用于治疗和预防的神经氨酸酶抑制剂敏感。禽流感在家禽中的广泛流行增加了突变事件和基因重组的可能性。禽流感未来大流行的威胁是真实的。充分的监测、疫苗的研制、爆发的准备和大流行性流感的规划都很重要。本文总结了目前对禽流感的认识，包括病毒学，流行病学，诊断和管理这一新出现的疾病。
In December 2003, the largest outbreak of highly pathogenic avian influenza H5N1 occurred among poultry in 8 Asian countries. A limited number of human H5N1 infections have been reported from Vietnam and Thailand, with a mortality rate approaching 70%. Deaths have occurred in otherwise healthy young individuals, which is reminiscent of the 1918 Spanish influenza pandemic. The main presenting features were fever, pneumonitis, lymphopenia, and diarrhea. Notably, sore throat, conjunctivitis, and coryza were absent. The H5N1 strains are resistant to amantadine and rimantadine but are susceptible to neuraminidase inhibitors, which can be used for treatment and prophylaxis. The widespread epidemic of avian influenza in domestic birds increases the likelihood for mutational events and genetic reassortment. The threat of a future pandemic from avian influenza is real. Adequate surveillance, development of vaccines, outbreak preparedness, and pandemic influenza planning are important. This article summarizes the current knowledge on avian influenza, including the virology, epidemiology, diagnosis, and management of this emerging disease.
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影响因子：
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