Time-locked acute alpha-frequency stimulation of subthalamic nuclei during the evaluation of emotional stimuli and its effect on power modulation.
Time-locked acute alpha-frequency stimulation of subthalamic nuclei during the evaluation of emotional stimuli and its effect on power modulation.
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情绪刺激评估期间丘脑底核的时间锁定急性α频率刺激及其对功率调制的影响。
DOI：
10.3389/fnhum.2023.1181635
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发表时间：
2023
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
针对丘脑底核（subthalamic nucleus，DBS）的帕金森病（Parkinson's disease，PD）脑深部电刺激（Deep brain stimulation，DBS）研究已经表征了其跨认知过程的频谱特性。在情绪评估任务中，已经证明了特定的α频率（8-12 Hz）与事件相关的去同步（ERD）（降低的功率）。相对于刺激开始的时间锁定的刺激，在10 Hz时显示出主观的正效价变化，但在130 Hz时没有。然而，尚未研究刺激对功率调制的神经生理学影响。我们的目的是研究急性刺激右小脑对对侧小脑和额部头皮EEG的并发功率调制的影响。从我们之前的研究中，我们有一个强有力的先验假设，即没有刺激的负面意象与α ERD相关; 130 Hz刺激的负面意象也与α ERD相关，因为它对主观效价评级没有影响; 10 Hz刺激的负面意象与增强的α功率相关，因为行为效价评级发生了变化。24名受试者接受了情绪图片观看任务，包括中性和消极的图片。在这些受试者的一个子集中，阴性图像与10或130 Hz的时间锁定急性刺激相关。相对于基线估计信号功效，并进行非参数统计检验。正如假设的那样，在130 Hz刺激条件下，无论刺激如何，我们都显示出负图像与中性图像的α功率降低。相反，在负10 Hz刺激条件下，这种α功率降低不再明显，与α功率的预测增加一致。10 Hz刺激条件下更大的β功率以及10 Hz刺激和未刺激条件下的β功率之间的相关性沿着表明生理和认知概括效应。急性α-特异性频率刺激可能与α-功率对负图像的预期降低或去极化的损失相关，这表明了促进α-功率同步和增强功率的能力。急性时间锁定刺激有可能提供因果洞察的频谱频率和时间动态的情绪处理。
Deep brain stimulation (DBS) studies in Parkinson's Disease (PD) targeting the subthalamic nucleus (STN) have characterized its spectral properties across cognitive processes. In emotional evaluation tasks, specific alpha frequency (8–12 Hz) event-related de-synchronization (ERD) (reduced power) has been demonstrated. The time-locked stimulation of STN relative to stimuli onset has shown subjective positive valence shifts with 10 Hz but not with 130 Hz. However, neurophysiological effects of stimulation on power modulation have not been investigated. We aim to investigate effects of acute stimulation of the right STN on concurrent power modulation in the contralateral STN and frontal scalp EEG. From our previous study, we had a strong a priori hypothesis that negative imagery without stimulation would be associated with alpha ERD; negative imagery with 130 Hz stimulation would be also associated with alpha ERD given the lack of its effect on subjective valence ratings; negative imagery with 10 Hz stimulation was to be associated with enhanced alpha power given the shift in behavioral valence ratings. Twenty-four subjects with STN DBS underwent emotional picture-viewing tasks comprising neutral and negative pictures. In a subset of these subjects, the negative images were associated with time-locked acute stimulation at either 10 or 130 Hz. Power of signals was estimated relative to the baseline and subjected to non-parametric statistical testing. As hypothesized, in 130 Hz stimulation condition, we show a decrease in alpha power to negative vs. neutral images irrespective of stimulation. In contrast, this alpha power decrease was no longer evident in the negative 10 Hz stimulation condition consistent with a predicted increase in alpha power. Greater beta power in the 10 Hz stimulation condition along with correlations between beta power across the 10 Hz stimulation and unstimulated conditions suggest physiological and cognitive generalization effects. Acute alpha-specific frequency stimulation presumably was associated with a loss of this expected decrease or desynchronization in alpha power to negative images suggesting the capacity to facilitate the synchronization of alpha and enhance power. Acute time-locked stimulation has the potential to provide causal insights into the spectral frequencies and temporal dynamics of emotional processing.
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影响因子：
3.9
作者：
Kim HJ;Jeon BS;Paek SH
通讯作者：
Paek SH
影响因子：
4.2
作者：
Irmen F;Huebl J;Schroll H;Brücke C;Schneider GH;Hamker FH;Kühn AA
通讯作者：
Kühn AA
晚期帕金森病的自适应深脑刺激。
影响因子：
11.2
作者：
Little, Simon;Pogosyan, Alex;Neal, Spencer;Zavala, Baltazar;Zrinzo, Ludvic;Hariz, Marwan;Foltynie, Thomas;Limousin, Patricia;Ashkan, Keyoumars;FitzGerald, James;Green, Alexander L.;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
3.4
作者：
Bruecke, C.;Kupsch, A.;Kuehn, A. A.
通讯作者：
Kuehn, A. A.
影响因子：
3
作者：
Buot, A.;Yelnik, J.
通讯作者：
Yelnik, J.