Subthalamic nucleus stimulation impairs emotional conflict adaptation in Parkinson's disease.
Subthalamic nucleus stimulation impairs emotional conflict adaptation in Parkinson's disease.
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DOI：
10.1093/scan/nsx090
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发表时间：
2017-10-01
影响因子：
4.2
通讯作者：
Kühn AA
中科院分区：
文献类型：
--
作者：
Irmen F;Huebl J;Schroll H;Brücke C;Schneider GH;Hamker FH;Kühn AA
丘脑下核（STN）在运动网络中占有重要地位，在知觉输入冲突的情况下减缓反应。最近的证据表明，通过与情绪识别结构的紧密联系，STN在情绪处理中起着重要作用。由于脑深部电刺激（DBS）对帕金森病（PD）患者的STN抑制了对知觉和价值冲突的监测，STN DBS也可能干扰情绪冲突加工。为了评估STN DBS对情绪冲突加工的可能干扰，我们使用了情绪Stroop范式。受试者根据他们的情绪表达对面部刺激进行分类，而忽略情绪一致或不一致的叠加词标签。11名PD患者和11名年龄匹配的健康受试者进行了这项任务。我们发现冲突诱发的反应在健康对照组和PD患者中减缓，但在DBS上没有，这表明STN DBS降低了对试验内冲突的适应。在无DBS的情况下，患者在负性冲突刺激下表现出更多的冲突诱发的减缓，而STN DBS则减少了这一现象。STN对冲突适应影响的计算模型揭示了DBS通过增加基线活动来干扰。
The subthalamic nucleus (STN) occupies a strategic position in the motor network, slowing down responses in situations with conflicting perceptual input. Recent evidence suggests a role of the STN in emotion processing through strong connections with emotion recognition structures. As deep brain stimulation (DBS) of the STN in patients with Parkinson’s disease (PD) inhibits monitoring of perceptual and value-based conflict, STN DBS may also interfere with emotional conflict processing. To assess a possible interference of STN DBS with emotional conflict processing, we used an emotional Stroop paradigm. Subjects categorized face stimuli according to their emotional expression while ignoring emotionally congruent or incongruent superimposed word labels. Eleven PD patients ON and OFF STN DBS and eleven age-matched healthy subjects conducted the task. We found conflict-induced response slowing in healthy controls and PD patients OFF DBS, but not ON DBS, suggesting STN DBS to decrease adaptation to within-trial conflict. OFF DBS, patients showed more conflict-induced slowing for negative conflict stimuli, which was diminished by STN DBS. Computational modelling of STN influence on conflict adaptation disclosed DBS to interfere via increased baseline activity.
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影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
2.6
作者：
Beall, Paula M.;Herbert, Andrew M.
通讯作者：
Herbert, Andrew M.
影响因子：
3.4
作者：
Bruecke, C.;Kupsch, A.;Kuehn, A. A.
通讯作者：
Kuehn, A. A.
影响因子：
3.7
作者：
Egner, Tobias;Etkin, Amit;Hirsch, Joy
通讯作者：
Hirsch, Joy
DOI：
10.1523/jneurosci.2259-12.2012
发表时间：
2012-09-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Brittain JS;Watkins KE;Joundi RA;Ray NJ;Holland P;Green AL;Aziz TZ;Jenkinson N
通讯作者：
Jenkinson N