Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.
Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.
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DOI：
10.1007/s00251-009-0408-5
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发表时间：
2010-02
期刊：
影响因子：
3.2
通讯作者：
Moffett, Ashley
中科院分区：
文献类型：
--
作者：
Hiby, Susan E.;Ashrafian-Bonab, Maziar;Farrell, Lydia;Single, Richard M.;Balloux, Francois;Carrington, Mary;Moffett, Ashley
杀伤细胞免疫球蛋白样受体(KIR)基因频率在不同种群之间存在差异，并与病毒免疫反应、自身免疫和繁殖成功的功能差异有关。本研究描述了生活在不同环境中的阿塞拜疆人和乔诺比人这两个世代生活在不同环境中的伊朗人的12个KIR基因及其HLAC配体的频率分布。这一结果与其他人群和一大群英国高加索人的研究结果进行了比较。两组间KIR和HLA-C组频率、连锁不平衡和抑制/激活KIR比率存在差异。KIR A和B单倍型频率和KIR AA基因频率与地理位置相近的人群相似，反映了他们的共同祖先。强调了KIR基因家族及其人类白细胞抗原-C配体的极端变异性，以及它们在确定地理上和文化上孤立的社区之间的差异方面的重要性，这些社区受到来自同一种族群体的不同环境压力。
Killer cell immunoglobulin-like receptors (KIR) gene frequencies vary between populations and contribute to functional variation in immune responses to viruses, autoimmunity and reproductive success. This study describes the frequency distribution of 12 variable KIR genes and their HLA-C ligands in two Iranian populations who have lived for many generations in different environments: the Azerbaijanis at high altitude and the Jonobi people at sea level. The results are compared with those published for other human populations and a large group of English Caucasians. Differences were seen in KIR and HLA-C group frequencies, in linkage disequilibrium and inhibitory/activating KIR ratios between the groups. Similarities with geographically close populations in the frequencies of the KIR A and B haplotypes and KIR AA genotype reflected their common ancestry. The extreme variability of the KIR gene family and their HLA-C ligands is highlighted and their importance in defining differences between geographically and culturally isolated communities subject to different environmental pressures who come from the same ethnic grouping.
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