Bilateral Interactions in the Mouse Dorsal Inferior Colliculus Enhance the Ipsilateral Neuronal Responses and Binaural Hearing.
Bilateral Interactions in the Mouse Dorsal Inferior Colliculus Enhance the Ipsilateral Neuronal Responses and Binaural Hearing.
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小鼠背下丘的双边相互作用增强同侧神经元反应和双耳听力
DOI：
10.3389/fphys.2022.854077
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发表时间：
2022
影响因子：
4
通讯作者：
Xiao, Zhongju
中科院分区：
文献类型：
--
作者：
Liu, Yun;Li, Yan;Peng, Yunyi;Yu, Haipeng;Xiao, Zhongju
下丘是双耳处理听觉信息的重要中枢。然而，以往的研究主要集中在下丘中央核（ICC）上，对下丘背核（ICD）的研究较少。在这里，我们首先研究了小鼠ICD中神经元反应的特征，并将其与双耳和单耳条件下下丘的神经元反应进行了比较。与ICC神经元相比，ICD神经元对同侧声音刺激表现出更强的反应和更好的双耳综合，这表明ICD在双耳听力整合中发挥了作用。根据逆行病毒追踪检测到的双边ICD之间丰富的相互作用，我们进一步研究了单侧ICD沉默对对侧ICD的影响。应用利多卡因后，部分ICD神经元（13/26）的反应，特别是对同侧听觉刺激的反应减弱。利用全细胞记录和光遗传学方法，我们研究了ICD中双耳听觉信息处理的神经回路和突触机制。单侧ICD向另一侧ICD提供兴奋性和抑制性投射，有利的兴奋性输入可能是ICD神经元同侧反应和双耳累计增强的原因。基于这些结果，对侧ICD可能调节同侧神经元的反应和双耳听力。
The inferior colliculus (IC) is a critical centre for the binaural processing of auditory information. However, previous studies have mainly focused on the central nucleus of the inferior colliculus (ICC), and less is known about the dorsal nucleus of the inferior colliculus (ICD). Here, we first examined the characteristics of the neuronal responses in the mouse ICD and compared them with those in the inferior colliculus under binaural and monaural conditions using in vivo loose-patch recordings. ICD neurons exhibited stronger responses to ipsilateral sound stimulation and better binaural summation than those of ICC neurons, which indicated a role for the ICD in binaural hearing integration. According to the abundant interactions between bilateral ICDs detected using retrograde virus tracing, we further studied the effect of unilateral ICD silencing on the contralateral ICD. After lidocaine was applied, the responses of some ICD neurons (13/26), especially those to ipsilateral auditory stimuli, decreased. Using whole-cell recording and optogenetic methods, we investigated the underlying neuronal circuits and synaptic mechanisms of binaural auditory information processing in the ICD. The unilateral ICD provides both excitatory and inhibitory projections to the opposite ICD, and the advantaged excitatory inputs may be responsible for the enhanced ipsilateral responses and binaural summation of ICD neurons. Based on these results, the contralateral ICD might modulate the ipsilateral responses of the neurons and binaural hearing.
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影响因子：
5.3
作者：
Wei J;Zhong W;Xiao C;Liu Y;Song C;Xiao Z
通讯作者：
Xiao Z
影响因子：
5.6
作者：
Liu, Xiao-Bo;Murray, Karl D.
通讯作者：
Murray, Karl D.
影响因子：
2.8
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He, Na;Kong, Lingzhi;Yan, Jun
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Yan, Jun
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Chen, Chenggang;Song, Sen
通讯作者：
Song, Sen
影响因子：
2.5
作者：
Gooler, DM;Xu, JH;Feng, AS
通讯作者：
Feng, AS