Cannabinoid receptor 1 (CNR1) gene variant moderates neural index of cognitive disruption during nicotine withdrawal.
Cannabinoid receptor 1 (CNR1) gene variant moderates neural index of cognitive disruption during nicotine withdrawal.
复制标题
大麻素受体1（CNR1）基因变体在尼古丁戒断期间会降低认知破坏的神经指数。
DOI：
10.1111/gbb.12311
复制
发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Drobes DJ
中科院分区：
文献类型：
--
作者：
Evans DE;Sutton SK;Jentink KG;Lin HY;Park JY;Drobes DJ
尼古丁戒断相关的认知控制中断可能有助于加强烟草使用。识别预测这种戒断表型的基因变异可能导致针对戒烟的量身定制的药物治疗。大麻素受体1基因（CNR 1）的变异与尼古丁依赖有关，CNR 1拮抗剂可能会增加注意力和记忆功能。我们将CNR 1变体作为尼古丁戒断相关认知障碍的经验证神经标志物的调节剂。CNR 1多态性包括“TAG”单倍型（rs 806379，rs 1535255和rs 2023239）进行了独立测试，因为该样本中没有参与者拥有该单倍型。尼古丁戒断相关认知障碍的指标为17个电极的静息脑电图（EEG）α-1功率密度增加。73名高加索非西班牙裔吸烟者（每天≥ 15支香烟）在整夜吸烟/尼古丁剥夺后两次访问实验室。在每次会议收集EEG数据之前，吸两支尼古丁或两支安慰剂香烟。分析表明，rs 806379调节了尼古丁剥夺增加慢波EEG的影响（p = .004）。吸烟者的主要等位基因纯合子表现出更大的尼古丁戒断相关的认知障碍。目前的研究结果表明，大麻素受体拮抗剂作为戒烟药物治疗方法在表现出更大尼古丁戒断相关认知障碍的个体中具有潜在疗效。
Nicotine withdrawal-related disruption of cognitive control may contribute to the reinforcement of tobacco use. Identification of gene variants that predict this withdrawal phenotype may lead to tailored pharmacotherapy for smoking cessation. Variation on the cannabinoid receptor 1 gene (CNR1) has been related to nicotine dependence, and CNR1 antagonists may increase attention and memory functioning. We targeted CNR1 variants as moderators of a validated neural marker of nicotine withdrawal-related cognitive disruption. CNR1 polymorphisms comprising the “TAG” haplotype (rs806379, rs1535255, and rs2023239) were tested independently, as no participants in this sample possessed this haplotype. Nicotine withdrawal-related cognitive disruption was indexed as increased resting electroencephalogram (EEG) alpha-1 power density across 17 electrodes. 73 Caucasian Non-Hispanic smokers (≥ 15 cigarettes per day) visited the laboratory on two occasions following overnight smoking/nicotine deprivation. Either two nicotine or two placebo cigarettes were smoked prior to collecting EEG data at each session. Analyses showed that rs806379 moderated the effects of nicotine deprivation increasing slow wave EEG (p = .004). Smokers homozygous for the major allele exhibited greater nicotine withdrawal-related cognitive disruption. The current findings suggest potential efficacy of cannabinoid RECEPTOR antagonism as a pharmacotherapy approach for smoking cessation among individuals who exhibit greater nicotine withdrawal-related cognitive disruption.
登录
查看更多内容
影响因子：
3.4
作者：
Terranova, JP;Storme, JJ;Soubrie, P
通讯作者：
Soubrie, P
影响因子：
10.6
作者：
Loo, SK;Teale, PD;Reite, ML
通讯作者：
Reite, ML
影响因子：
3.6
作者：
Degroot, Aldemar;Kofalvi, Attila;Nomikos, George G.
通讯作者：
Nomikos, George G.
影响因子：
3.6
作者：
Evans, David E.;Jentink, Kade G.;Drobes, David J.
通讯作者：
Drobes, David J.
影响因子：
3.4
作者：
Sutton, Steven K.;Van Rensburg, Kate Janse;Evans, David E.
通讯作者：
Evans, David E.