Age-related increase of resting metabolic rate in the human brain.
Age-related increase of resting metabolic rate in the human brain.
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DOI：
10.1016/j.neuroimage.2014.04.078
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发表时间：
2014-09
期刊：
影响因子：
5.7
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Peng SL;Dumas JA;Park DC;Liu P;Filbey FM;McAdams CJ;Pinkham AE;Adinoff B;Zhang R;Lu H
随着年龄的增长，大脑结构的许多方面都出现了明显的衰退，但个体通常在老年之前都能正常工作。在大脑老化中似乎有几种补偿机制，但它们的确切性质还没有得到很好的表征。在这里，我们提供的证据表明，与年轻人相比，老年人的大脑消耗更多的能量，表现为脑氧代谢率（CMRO2）的年龄相关性增加（P=0.03）（N=118，男性=56，年龄18至74岁）。我们进一步表明，在平均绝经年龄51岁之前，女性和男性组的CMRO2增加率相似（P=0.015），年龄和性别之间没有相互作用（P=0.85）。然而，当使用来自整个年龄范围的数据时，与男性相比，女性的CMRO2变化速率较慢（年龄×性别交互作用项P<0.001）。因此，更年期和雌激素水平可能在这种性别差异中发挥了作用。我们的数据还揭示了CMRO2可能的昼夜节律，即中午的脑代谢率高于早晨（P=0.02）。这项研究揭示了一个潜在的神经生物学机制，年龄相关的补偿在脑功能，也提出了性别差异的时间模式。
With age, many aspects of the brain structure undergo a pronounced decline, yet individuals generally function well until advanced old age. There appear to be several compensatory mechanisms in brain aging, but their precise nature is not well characterized. Here we provide evidence that the brain of older adults expends more energy when compared to younger adults, as manifested by an age-related increase (P=0.03) in cerebral metabolic rate of oxygen (CMRO2) (N=118, men=56, ages 18 to 74). We further showed that, before the mean menopausal age of 51 years old, female and male groups have similar rates of CMRO2 increase (P=0.015) and there was no interaction between age and sex effects (P=0.85). However, when using data from the entire age range, women have a slower rate of CMRO2 change when compared to men (P<0.001 for age × sex interaction term). Thus, menopause and estrogen level may have played a role in this sex difference. Our data also revealed a possible circadian rhythm of CMRO2 in that brain metabolic rate is greater at noon than in the morning (P=0.02). This study reveals a potential neurobiological mechanism for age-related compensation in brain function and also suggests a sex-difference in its temporal pattern.
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DOI：
10.1093/geronj/47.1.b26
发表时间：
1992-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
LIM, KO;ZIPURSKY, RB;PFEFFERBAUM, A
通讯作者：
PFEFFERBAUM, A
影响因子：
14.5
作者：
Daselaar, SM;Veltman, DJ;Jonker, C
通讯作者：
Jonker, C
影响因子：
4.8
作者：
Geerligs, Linda;Maurits, Natasha M.;Lorist, Monicque M.
通讯作者：
Lorist, Monicque M.
影响因子：
9.9
作者：
Guttmann, CRG;Jolesz, FA;Albert, MS
通讯作者：
Albert, MS
影响因子：
2.6
作者：
EUSTACHE, F;RIOUX, P;BARON, JC
通讯作者：
BARON, JC