Medial prefrontal cortex activity can disrupt the expression of stress response habituation.
Medial prefrontal cortex activity can disrupt the expression of stress response habituation.
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DOI：
10.1016/j.neuroscience.2010.04.006
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发表时间：
2010-07-14
期刊：
影响因子：
3.3
通讯作者：
Spencer, R. L.
中科院分区：
文献类型：
--
作者：
Weinberg, M. S.;Johnson, D. C.;Bhatt, A. P.;Spencer, R. L.
最近的研究表明，大鼠下丘脑-垂体-肾上腺轴应激反应适应的表达依赖于自上而下的神经控制。因此，我们研究了内侧前额叶皮层（mPFC）是否调节应激反应习惯化的表达。我们暂时抑制（微注射muscimol）或刺激（微注射picrotoxin）大鼠mPFC神经活动，并分别研究了对心理应激（约束）的首次反应和对重复约束的习惯性发育和表达的影响。我们监测了激素（皮质酮）和神经（前脑c-fos mRNA）对压力的反应。mPFC失活对首次抑制时hpa轴的反应没有影响，但mPFC活性的增加会减弱应力诱导的hpa轴活性。在3天的重复约束应激方案中，mPFC在第1天和第2天失活，而不是在第3天，阻止了hpa轴激素反应习惯化的表达。在这些大鼠中，第3天的mPFC活动选择性地干扰了mPFC、外侧隔和下丘脑室旁核内c-fos mRNA习惯化的表达。相比之下，仅在第3天或所有3天的mPFC失活都不会干扰习惯化的表达。我们的结论是，mPFC可以允许或破坏hpa轴应激反应习惯的表达，这种控制取决于选定脑区域内神经活动的改变。这些发现的一个可能的含义是，与抑郁症和创伤后应激障碍相关的PFC活动失调可能导致应激反应适应的表达受损，从而加剧这些疾病。
Recent findings suggest that the expression of hypothalamic-pituitary-adrenal (HPA) axis stress response adaptation in rats depends on top-down neural control. We therefore examined whether the medial prefrontal cortex (mPFC) modulates expression of stress response habituation. We transiently suppressed (muscimol microinfusion) or stimulated (picrotoxin microinfusion) mPFC neural activity in rats and studied the consequence on the first time response to psychological stress (restraint) or separately on the development and expression of habituation to repeated restraint. We monitored both the hormonal (corticosterone) and neural (forebrain c-fos mRNA) response to stress. Inactivation of the mPFC had no effect on the HPA-axis response to first time restraint, however increased mPFC activity attenuated stress-induced HPA-axis activity. In a three day repeated restraint stress regimen, inactivation of the mPFC on days 1 and 2, but not day 3, prevented the expression of HPA-axis hormone response habituation. In these same rats, the mPFC activity on day 3 interfered with the expression of c-fos mRNA habituation selectively within the mPFC, lateral septum and hypothalamic paraventricular nucleus. In contrast, inactivation of the mPFC only on day 3, or on all 3 days did not interfere with the expression of habituation. We conclude that the mPFC can permit or disrupt expression of HPA-axis stress response habituation, and this control depends on alteration of neural activity within select brain regions. A possible implication of these findings is that the dysregulation of PFC activity associated with depression and post-traumatic stress disorder may contribute to impaired expression of stress-response adaptation and consequently exacerbation of those disorders.
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影响因子：
3.4
作者：
Figueiredo, HF;Bruestle, A;Herman, JP
通讯作者：
Herman, JP
影响因子：
2
作者：
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通讯作者：
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影响因子：
3.2
作者：
Lapiz-Bluhm MD;Bondi CO;Doyen J;Rodriguez GA;Bédard-Arana T;Morilak DA
通讯作者：
Morilak DA
影响因子：
2.7
作者：
Edeline, JM;Hars, B;Cotillon, N
通讯作者：
Cotillon, N
影响因子：
3.3
作者：
Girotti, M;Pace, TWW;Spencer, RL
通讯作者：
Spencer, RL