Training the domestic ferret to discriminate odors associated with wildlife disease.
Training the domestic ferret to discriminate odors associated with wildlife disease.
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DOI：
10.1371/journal.pone.0259415
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Kimball BA
中科院分区：
文献类型：
--
作者：
Golden GJ;Opiekun M;Martin-Taylor T;Kimball BA
最近禽流感感染的爆发引起了全球对生物安全和经济的关注。野鸭对这种疾病没有症状，可能会沿着候鸟的飞行路线传播禽流感。在之前的一项研究中，当将感染后期的粪便与感染前期的粪便配对时，经过训练的小鼠根据粪便气味正确地区分了个体鸭子的健康状况。化学分析表明，禽流感感染与粪便中乙酮（3-羟基-2-丁酮）的显著增加有关。在目前的研究中，驯化的雄性雪貂（Mustela putorius furo）被训练为对乙酰托因：1-辛烯-3-醇溶液中乙酰托因的显著增加做出特定的条件反应（即主动抓伤警报）。雪貂对感染禽流感的野鸭放射的粪便的气味迅速概括了这种习得的反应。这些结果表明，经过训练的哺乳动物生物传感器可用于禽流感监测项目。
Recent avian influenza infection outbreaks have resulted in global biosecurity and economic concerns. Mallards are asymptomatic for the disease and can potentially spread AI along migratory bird flyways. In a previous study, trained mice correctly discriminated the health status of individual ducks on the basis of fecal odors when feces from post-infection periods were paired with feces from pre-infection periods. Chemical analyses indicated that avian influenza infection was associated with a marked increase of acetoin (3-hydroxy-2-butanone) in feces. In the current study, domesticated male ferrets (Mustela putorius furo) were trained to display a specific conditioned response (i.e. active scratch alert) in response to a marked increase of acetoin in a presentation of an acetoin:1-octen-3-ol solution. Ferrets rapidly generalized this learned response to the odor of irradiated feces from avian influenza infected mallards. These results suggest that a trained mammalian biosensor could be employed in an avian influenza surveillance program.
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影响因子：
5.4
作者：
Havermans, Remco C.;Salvy, Sarah-Jeanne;Jansen, Anita
通讯作者：
Jansen, Anita
影响因子：
3.7
作者：
Hernadi, Anna;Kis, Anna;Topal, Jozsef
通讯作者：
Topal, Jozsef
影响因子：
2.3
作者：
Walker, DB;Walker, JC;Suarez, JC
通讯作者：
Suarez, JC
影响因子：
2.9
作者：
Kimball, Bruce A.;Opiekun, Maryanne;Beauchamp, Gary K.
通讯作者：
Beauchamp, Gary K.
DOI：
10.1073/pnas.87.21.8413
发表时间：
1990-11-01
影响因子：
11.1
作者：
YAMAZAKI, K;BEAUCHAMP, GK;BOYSE, EA
通讯作者：
BOYSE, EA