Neural sensitivity to peer feedback and depression symptoms in adolescents: a 2-year multiwave longitudinal study.
Neural sensitivity to peer feedback and depression symptoms in adolescents: a 2-year multiwave longitudinal study.
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DOI：
10.1111/jcpp.13690
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发表时间：
2023-03
影响因子：
7.6
通讯作者：
Auerbach, Randy P.
中科院分区：
文献类型：
--
作者：
Pagliaccio, David;Kumar, Poornima;Kamath, Rahil A.;Pizzagalli, Diego A.;Auerbach, Randy P.
在青春期，抑郁的风险会增加，而个体对同伴反馈(拒绝与接受)的神经敏感度的差异可能是理解压力相关抑郁风险的关键因素。在基线时，青少年(12-14岁；N=124)完成临床访谈和自我报告症状测量，并在获取MRI数据的同时完成聊天室任务。大多数参与者提供了有用的磁共振数据(N=90；76%女性)，其中包括没有母亲抑郁史的青少年(低风险n=)和有母亲抑郁史的青少年(高危n=26)。全脑回归模型探索了同伴反馈后神经敏感度的群体差异，而全脑线性混合效应模型在长达2年的9次纵向评估中，通过与抑郁症状相关的同伴压力交互作用，检验了神经对同伴反馈的敏感性。全脑集群校正的结果表明，随着时间的推移，大脑激活减缓了同伴之间人际压力和抑郁之间的强烈正相关。这包括在预期和接受反馈(即拒绝与接受)时激活前脑岛、扣带回、杏仁核和纹状体。在考察同伴之间的人际(与非人际)压力以及与抑郁(与社交焦虑)症状的关系时，缓和效应更强。在关键的社会和激励处理大脑区域对同伴反馈的神经反应可能反映了核心倾向风险因素，这些因素与同伴人际压力相互作用，随着时间的推移预测青少年抑郁症状的严重程度。
Depression risk increases during adolescent development, and individual differences in neural sensitivity to peer feedback (rejection vs. acceptance) may be a key diathesis in understanding stress-related depression risk. At baseline, adolescents (12–14 years old; N = 124) completed clinical interviews and self-report symptom measures, and the Chatroom Task while MRI data were acquired. The majority of participants provided usable MRI data (N = 90; 76% female), which included adolescents with no maternal depression history (low risk n = 64) and those with a maternal depression history (high risk n = 26). Whole-brain regression models probed group differences in neural sensitivity following peer feedback, and whole-brain linear mixed-effects models examined neural sensitivity to peer feedback by peer stress interactions relating to depression symptoms at up to nine longitudinal assessments over 2 years. Whole-brain cluster-corrected results indicated brain activation moderating the strong positive association between peer interpersonal stress and depression over time. This included activation in the anterior insula, cingulate, amygdala, and striatum during anticipation and receipt of feedback (i.e., rejection vs. acceptance). Moderation effects were stronger when examining peer interpersonal (vs. non-interpersonal) stress and in relation to depression (vs. social anxiety) symptoms. Neural responses to peer feedback in key social and incentive processing brain regions may reflect core dispositional risk factors that interact with peer interpersonal stressors to predict adolescent depression symptom severity over time.
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影响因子：
11
作者：
Colodro-Conde L;Couvy-Duchesne B;Zhu G;Coventry WL;Byrne EM;Gordon S;Wright MJ;Montgomery GW;Madden PAF;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Ripke S;Eaves LJ;Heath AC;Wray NR;Medland SE;Martin NG
通讯作者：
Martin NG
影响因子：
7.6
作者：
Auerbach, Randy P.;Pisoni, Angela;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
3.7
作者：
Esteban, Oscar;Birman, Daniel;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
3.6
作者：
Auerbach, Randy Patrick;Bigda-Peyton, Joseph S.;Ho, Moon-Ho Ringo
通讯作者：
Ho, Moon-Ho Ringo